摘要
目的:评价玻璃体腔注射抗血管内皮生长因子(VEGF)、全视网膜激光光凝术(PRP)先后应用顺序不同治疗重度非增殖期糖尿病视网膜病变的临床效果。方法:选取2020年1月—2021年12月中山大学附属第五医院收治的41例(72眼)重度非增殖期糖尿病视网膜病变患者作为研究对象,随机分为顺序1组21例(33眼),顺序2组20例(39眼)。顺序1组采用连续3次玻璃体腔内注射抗VEGF治疗后进行PRP,顺序2组完成PRP后连续3次玻璃体腔内注射抗VEGF治疗。比较两组最佳矫正视力(BCVA)和黄斑中心凹视网膜厚度(CMT)。结果:治疗后3、6、9、12个月,两组BCVA低于治疗前,且治疗后6、9、12个月,顺序1组BCVA低于顺序2组,差异有统计学意义(P<0.05)。治疗后3、6、9、12个月,两组CMT逐渐降低,且治疗后6、9、12个月,顺序1组CMT低于顺序2组,差异有统计学意义(P<0.05)。结论:玻璃体腔注射抗VEGF、PRP先后应用顺序不同均能有效治疗重度非增殖期糖尿病视网膜病变,但是先应用玻璃体腔注射抗VEGF,后行PRP治疗的BCVA更低,视力改善更佳,CMT下降更明显。
Objective:To evaluate the clinical effect of intravitreal injection of anti-vascular endothelial growth factor(VEGF)and panretinal photocoagulation(PRP)in different sequences in the treatment of severe non-proliferative diabetic retinopathy.Methods:A total of 41 patients(72 eyes)with severe non-proliferative diabetic retinopathy who were treated in the Fifth Affiliated Hospital of Sun Yat-sen University from January 2020 to December 2021 were selected as the study subjects.They were randomly divided into sequence group 1(21 cases,33 eyes)and sequence group 2(20 cases,39 eyes).The sequence group 1 was treated with 3 consecutive intravitreal injections of anti-VEGF followed by PRP,and sequence group 2 was treated with PRP followed by 3 consecutive intravitreal injections of anti-VEGF.The best-corrected visual acuity(BCVA)and central macular thickness(CMT)were compared between the two groups.Results:At 3,6,9 and 12 months after treatment,the BCVA in the two groups was lower than that before treatment,at 6,9 and 12 months after treatment,the BCVA in the sequence group 1 was lower than that in the sequence group 2,and the difference was statistically significant(P<0.05).At 3,6,9 and 12 months after treatment,CMT in two groups gradually decreased,at 6,9 and 12 months after treatment,the CMT in the sequence group 1 was lower than that in the sequence group 2,and the difference was statistically significant(P<0.05).Conclusion:Intravitreal injection of anti-VEGF and PRP in different sequences can effectively treat severe non-proliferative diabetic retinopathy.However,the treatment of first intravitreal injection of anti-VEGF and then PRP achieves a lower BCVA,a better improvement in visual acuity and an obvious decline in CMT.
作者
郑晖
赵晓静
Zheng Hui;Zhao Xiaojing(The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,Guangdong Province,China)
出处
《中国社区医师》
2024年第5期14-16,共3页
Chinese Community Doctors
基金
广东省中医药局科研项目(编号:20201070)。
