摘要
目的 探讨血清总Ⅰ型前胶原氨基端前肽(PINP)和β-Ⅰ型胶原交联羧基末端肽(β-CTX)联合检测对早期预测长骨骨折延迟愈合的临床价值。方法 测定156例四肢长骨骨折患者术后1、4、8、12周时的血清PINP和β-CTX水平,根据骨折愈合情况将患者分为延迟愈合组(30例)和正常愈合组(126例),比较两组的血清PINP和β-CTX水平。采用logistic回归分析四肢长骨骨折延迟愈合的影响因素,并采用ROC曲线分析术后血清PINP和β-CTX联合检测对四肢长骨骨折延迟愈合的早期预测效能。结果 两组骨折术后血清PINP和β-CTX水平呈升高趋势,在治疗后8周达高峰,随后下降。骨折术后4、8、12周时,延迟愈合组血清PINP和β-CTX水平均低于正常愈合组,差异有统计学意义(P <0.05)。多因素logistic回归分析结果显示,术后血清PINP和β-CTX水平是四肢长骨骨折延迟愈合的独立危险因素(P <0.05)。ROC曲线显示,术后血清PINP和β-CTX联合检测预测长骨骨折延迟愈合的ROC曲线下面积(AUC)为0.861(P <0.05)。结论 术后血清PINP和β-CTX水平与四肢长骨骨折延迟愈合密切相关,二者联合检测有助于早期预测四肢长骨骨折延迟愈合。
Objective To investigate the clinical value of serum total type I procollagen amino terminal peptide(PINP) and type I collagen carboxyl terminal peptide(β-CTX) combined detection for early prediction of delayed healing of long bone fractures.Methods Serum PINP and β-CTX levels were measured in 156 patients with long bone fracture at 1,4,8,12 weeks after operation.The patients were divided into a delayed healing group(30 cases) and a normal healing group(126 cases) according to the healing status of the fracture.Logistic regression was used to analyze the influencing factors of delayed union of limbs long bone fractures,and ROC curve was used to analyze the early prediction efficiency of postoperative serum PINP and β-CTX combined detection on delayed union of limbs long bone fractures.Results The serum PINP and β-CTX levels in both groups showed an increasing trend after fracture surgery,reaching a peak at 8 weeks after treatment,and then decreasing.The levels of serum PINP and β-CTX in the delayed healing group were lower than those in the normal healing group at 4,8 and 12 hours after fracture operation,and the difference was statistically significant(P < 0.05).Multivariate Logistic regression analysis showed that postoperative serum PINP and β-CTX levels were independent risk factors for delayed healing of limb long bone fractures(P < 0.05).ROC curve showed that the AUC of postoperative serum PINP and β-CTX combined detection in predicting delayed union of long bone fractures was 0.861(P < 0.05).Conclusion Postoperative serum PINP and β-CTX levels are closely related to delayed union of limb long bone fractures,and the combined detection of PINP and β-CTX is helpful to early prediction of delayed union of limb long bone fractures.
作者
郝素平
王伟
李生文
HAO Supping;WANG Wei;LI Shengwen(Department of Clinical Laboratory,People's Hospital of Haining,Haining 314400,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第8期1148-1152,共5页
The Journal of Practical Medicine
基金
浙江省医药卫生科技计划项目(编号:2023KY1231)
海宁市科技计划项目(编号:2022096)。
