摘要
目的:探讨注射用复方甘草酸单铵S联合恩替卡韦治疗慢性乙型病毒性肝炎患者的效果及对肠道菌群的影响。方法:选取2021年1月—2022年7月毕节市中医医院收治的82例慢性乙型病毒性肝炎患者作为观察对象。按照入院时间顺序分组,将2021年1—10月收治的患者纳入对照组,2021年11月—2022年7月收治的患者纳入观察组,各41例。对照组采用恩替卡韦单独治疗,观察组则采用恩替卡韦联合注射用复方甘草酸单铵S治疗。观察两组总有效率,并分析治疗前后肝纤维化指标水平、肠道菌群数量。结果:治疗后,观察组总有效率为92.68%,高于对照组的75.61%,差异有统计学意义(P<0.05)。治疗后,观察组透明质酸酶(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组肠球菌、大肠杆菌数量少于对照组,乳酸杆菌、双歧杆菌、拟杆菌数量多于对照组,差异有统计学意义(P<0.05)。结论:应用恩替卡韦联合注射用复方甘草酸单铵S治疗慢性乙型病毒性肝炎患者,可有效降低肝纤维化指标水平,平衡肠道菌群数量,疗效显著。
Objective:To explore the effect of Compound Ammonium Glycyrrhetate S for Injection combined with Entecavir in the treatment of chronic viral hepatitis B patients and the effect on intestinal flora.Method:A total of 82 patients with chronic viral hepatitis B treated in Bijie Hospital of Traditional Chinese Medicine from January 2021 to July 2022 were selected as the observation objects.Patients admitted from January to October 2021 were included in the control group,and those admitted from November 2021 to July 2022 were included in the observation group,with 41 cases in each group.The control group was treated with Entecavir alone,and the observation group was treated with Entecavir combined with Compound Ammonium Glycyrrhetate S for Injection.The total effective rate of the two groups was observed,and the liver fibrosis index level and intestinal flora number before and after treatment were analyzed.Result:After treatment,the total effective rate of observation group was 92.68%,which was higher than 75.61% of control group,the difference was statistically significant(P<0.05).After treatment,hyaluronidase(HA),laminin(LN),type Ⅲ procollagen(PC-Ⅲ)and type Ⅳ collagen(Ⅳ-C)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,the number of Enterococcus and Escherichia coli in observation group were less than those in control group,while the number of Lactobacillus,Bifidobacterium and Bacteroides in observation group were more than those in control group,the differences were statistically significant(P<0.05).Conclusion:Entecavir combined with Compound Ammonium Glycyrrhetate S for Injection in the treatment of chronic viral hepatitis B patients can effectively reduce the level of liver fibrosis indexes and balance the number of intestinal flora,with significant efficacy.
作者
杨槐
YANG Huai(Bijie Hospital of Traditional Chinese Medicine,Bijie 551700,China)
出处
《中外医学研究》
2024年第5期112-115,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
