摘要
目的:探讨尼可地尔对ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心功能及不良心血管事件发生的影响。方法:选择2020年6月—2022年6月于莆田学院附属医院就诊的76例STEMI患者作为研究对象,按随机数表法将其分为对照组与观察组,各38例。两组术前均接受常规抗血小板、降压药物治疗,对照组行常规PCI手术,在对照组基础上观察组加用尼可地尔治疗。比较两组心功能、炎症因子水平及主要心血管不良事件(MACE)发生情况。结果:术后6个月,两组左心室舒张末期内径(LVEDD)、左心室收缩末期容积指数(LVESVI)均低于术前,左室射血分数(LVEF)、峰值射血率(PER)均高于术前,差异有统计学意义(P<0.05);相较于对照组,观察组术后6个月LVEDD、LVESVI较低,LVEF、PER较高,差异有统计学意义(P<0.05)。术后6个月,两组髓过氧物酶(MPO)、C反应蛋白(CRP)、白细胞介素-6(IL-6)及B型脑钠肽(BNP)水平均低于术前,且观察组低于对照组,差异有统计学意义(P<0.05)。相较于对照组,观察组术后6个月MACE发生率较低,差异有统计学意义(P<0.05)。结论:STEMI患者PCI术后应用尼可地尔治疗效果确切,利于改善术后心功能指标,降低炎症因子水平,且MACE发生率较低。
Objective:To investigate the effect of Nicorandil on cardiac function and adverse cardiovascular events in patients with ST segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Method:A total of 76 STEMI patients who admitted to Affiliated Hospital of Putian University from June 2020 to June 2022 were selected as the study objects,and they were divided into the control group and the observation group according to the random number table method,with 38 patients in each group.Two groups were treated with conventional antiplatelet and antihypertensive drugs before operation,and the control group was treated with conventional PCI,while the observation group was additional given Nicorandil on the basis of the control group.The cardiac function,inflammatory factor levels and major adverse cardiovascular events(MACE)between two groups were compared.Result:At 6 months after operation,the left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic volume index(LVESVI)in two groups were lower than those before operation,and the left ventricular ejection fraction(LVEF)and peak ejection rate(PER)were higher than those before operation,the differences were statistically significant(P<0.05);compared with the control group,the observation group had lower LVEDD and LVESVI,higher LVEF and PER at 6 months after operation,and the differences were statistically significant(P<0.05).At 6 months after operation,the levels of myeloperoxidase(MPO),C-reactive protein(CRP),interleukin-6(IL-6)and B-type brain natriuretic peptide(BNP)in two groups were lower than those before operation,and those in the observation group were lower than the control group,the differences were statistically significant(P<0.05).Compared with the control group,the observation group had a lower overall incidence of MACE at 6 months after surgery,the difference was statistically significant(P<0.05).Conclusion:Nicorandil is effective in the treatment of STEMI patients after PCI,which is beneficial to improve the postoperative cardiac function index,reduce the level of inflammatory factors,and the incidence of MACE is low.
作者
黄珊娇
HUANG Shanjiao(Affiliated Hospital of Putian University,Putian 351100,China)
出处
《中外医学研究》
2024年第6期55-59,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
ST段抬高型心肌梗死
经皮冠状动脉介入术
尼可地尔
心功能
炎症因子
心血管不良事件
ST segment elevation myocardial infarction
Percutaneous coronary intervention
Nicorandil
Cardiac function
Inflammatory factors
Cardiovascular adverse events
