摘要
目的:探讨左甲状腺素钠片治疗妊娠期糖尿病伴亚临床甲状腺功能减退(简称甲减)的效果及对妊娠并发症的影响。方法:选取2020年10月—2022年10月靖远县人民医院收治的80例妊娠期糖尿病伴亚临床甲减患者作为研究对象,以电脑产生随机数法将其分为对照组和观察组,各40例。两组均给予常规治疗,对照组加用甲状腺片,观察组加用左甲状腺素钠片,比较两组甲状腺功能、血糖水平、胰岛功能、妊娠并发症及不良反应情况。结果:治疗前,两组促甲状腺激素(TSH)水平比较,差异无统计学意义(P>0.05);治疗后,两组TSH水平明显低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组治疗前后游离四碘甲状腺原氨酸(FT4)、游离三碘甲状腺原氨酸(FT3)水平比较,差异无统计学意义(P>0.05)。两组治疗前空腹血糖、餐后2 h血糖比较,差异无统计学意义(P>0.05);但两组治疗后空腹血糖、餐后2 h血糖均低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组空腹胰岛素、空腹C肽水平比较,差异无统计学意义(P>0.05);治疗后,两组空腹胰岛素、空腹C肽水平高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组妊娠并发症发生率低于对照组,差异有统计学意义(P<0.05)。两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:左甲状腺素钠片治疗妊娠期糖尿病伴亚临床甲减患者,可提升甲状腺功能,改善血糖水平和胰岛功能,减少妊娠并发症发生。
Objective:To investigate the effect of Levothyroxine Sodium Tablets in the treatment of gestational diabetes with subclinical hypothyroidism and its influence on pregnancy complications.Method:A total of 80 patients with gestational diabetes and subclinical hypothyroidism who admitted to Jingyuan County People's Hospital from October 2020 to October 2022 were selected as the research objects,they were divided into the control group and the observation group by computer-generated random number method,with 40 cases in each group.Both groups were given conventional treatment,the control group was treated with Thyroid Tablets,and the observation group was treated with Levothyroxine Sodium Tablets.The thyroid function,blood glucose level,islet function,pregnancy complications and adverse reactions were compared between two groups.Result:Before treatment,there was no significant difference in the thyroid stimulating hormone(TSH)level between two groups(P>0.05);after treatment,the TSH levels of two groups were significantly lower than those before treatment,and that in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).There were no significant differences in the levels of free tetraiodothyronine(FT4)and free triiodothyronine(FT3)between the two groups(P>0.05).There were no significant differences in fasting blood glucose and 2 h postprandial blood glucose between two groups before treatment(P>0.05);however,the fasting blood glucose and 2 h postprandial blood glucose of two groups after treatment were lower than those before treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of fasting insulin and fasting C-peptide between two groups(P>0.05);after treatment,the levels of fasting insulin and fasting C-peptide in two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The incidence of pregnancy complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between two groups during treatment(P>0.05).Conclusion:The application of Levothyroxine Sodium Tablet in the treatment of patients with gestational diabetes and subclinical hypothyroidism can improve the thyroid function,improve blood glucose levels and islet function,reduce pregnancy complications.
作者
李凌梅
章小宏
LI Lingmei;ZHANG Xiaohong(Jingyuan County People's Hospital,Jingyuan 730600,China;不详)
出处
《中外医学研究》
2024年第6期59-63,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
