摘要
目的探讨血清神经调节蛋白4(Nrg4)水平与糖尿病微血管并发症(DMC)的关系。方法136例2型糖尿病(T2DM)患者根据是否合并DMC分为DMC组77例和非DMC组59例。收集患者临床资料,测定血清Nrg4水平,采用多因素logistic回归分析T2DM合并DMC的影响因素,ROC曲线分析Nrg4对T2DM合并DMC的预测价值。结果与非DMC组比较,DMC组年龄较大,糖尿病病程较长,尿微量白蛋白较高,血清Nrg4水平较低(P<0.05)。糖尿病病程较长是T2DM合并DMC的独立危险因素(P<0.05),血清Nrg4水平较高是其保护性因素(P<0.05)。Nrg4预测T2DM合并DMC的AUC为0.730[95%CI(0.644~0.817),P<0.05],取最佳诊断界值为5.87 pg/mL时,预测的灵敏度为92.2%,特异度为45.8%。结论T2DM合并DMC患者血清Nrg4水平降低,Nrg4对其有一定的预测价值。
Objective To explore the relationship of serum neuregulin 4(Nrg4)level with diabetic microvascular complication(DMC).Methods A total of 136 patients with type 2 diabetes mellitus(T2DM)were divided into DMC group and non-DMC group.The clinical data were collected and serum Nrg4 level was measured.The influencing factors for T2DM combined with DMC were analyzed by multivariate logistic regression,and the predictive value of Nrg4 for T2DM combined with DMC was analyzed by ROC curve.Results Compared with non-DMC group,the age was older,duration of diabetes was longer,microalbuminuria was higher,and serum Nrg4 level was lower in DMC group(P<0.05).The longer duration of diabetes was the independent risk factor for T2DM combined with DMC(P<0.05),and higher serum level of Nrg4 was the protective factor(P<0.05).The AUC value of Nrg4 predicting T2DM combined with DMC was 0.730[95%CI(0.644-0.817),P<0.05].When the best diagnostic threshold was 5.87 pg/mL,the sensitivity and specificity of the prediction were 92.2%and 45.8%,respectively.Conclusion Serum Nrg4 level is decreased in T2DM patients combined with DMC.Nrg4 has certain predictive value for DMC.
作者
王玉颖
朱晓慧
潘霞
孙科
李婷婷
江冬梅
WANG Yuying;ZHU Xiaohui;PAN Xia(Department of Endocrinology,Yancheng School of Clinical Medicine,Nanjing Medical University,Yancheng 224000,CHINA)
出处
《江苏医药》
CAS
2024年第3期242-244,249,共4页
Jiangsu Medical Journal
基金
江苏省卫健委员会科研项目(Z2022098)
盐城市科技计划项目(YK2018121)。
