摘要
目的 考察脯氨酸丹参素冰片酯对小鼠中枢神经系统的影响。方法 将小鼠随机分为对照组和脯氨酸丹参素冰片酯大剂量(120 mg/kg)、中剂量(60 mg/kg)、小剂量(30 mg/kg)给药组,每组10只,雌雄各半,灌胃给药后考察对小鼠自主活动、协同睡眠、协调运动能力和镇痛的作用。结果 与对照组相比,脯氨酸丹参素冰片酯对小鼠自主活、协同睡眠、协调运动能力和镇痛方面无显著影响。结论 脯氨酸丹参素冰片酯对小鼠中枢神经系统无明显影响,在药效有效剂量范围内安全性较好。
Objective To explore the effects of proline danshensu borneol ester on the central nervous system of mice.Methods Mice were randomly divided into control,proline danshensu borneol ester 120 mg/kg,60 mg/kg and 30 mg/kg group,each group including 10 mice which were half male and half female.The changes in spontaneous activity,synergistic sleep,coordinated movement and analgesic effect in mice were observed.Results Compared with control group,proline danshensu borneol ester there were no effect on mice's spontaneous activity,synergistic sleep,coordinated movement and analgesic effect.Conclusion Proline danshensu borneol ester there was no significant effects on the central nervous system of mice,revealing high safety during the range of pharmacodynamic effective dose.
作者
秦蓓
王荣
余丽丽
张怡心
谭雄
王娜娜
Qin Bei;Wang Rong;Yu Lili;Zhang Yixin;Tan Xiong;Wang Nana(Xi’an Key Laboratory of Multisynergistic Antihypertensive Innovative Drug Development,Xi’an Medical University,Xi’an 710021,Shanxi,China;Institute of Drug Research,Xi’an Medical University,Xi’an 710021,Shanxi,China;College of Pharmacy,Xi’an Medical University,Xi’an 710021,Shanxi,China)
出处
《贵州医药》
CAS
2024年第4期524-526,531,共4页
Guizhou Medical Journal
基金
陕西省重点研发计划项目(2021ZDLSF03-05)
陕西省科技厅自然科学基础研究计划项目(2022JM-492)
陕西省高校青年创新团队建设项目(陕教函[2022]943号)
西安医学院校级科技创新团队(2021TD03、07)
教育部产学合作协同育人项目(202101021043,220605634241456)。
关键词
脯氨酸丹参素冰片酯
一般药理学
中枢神经系统
小鼠
Proline danshensu borneol ester
General pharmacology
Central nervous system
Mice
