摘要
目的筛选制备海藻酸钠-丙烯酸树脂冰片微囊(SA/RS 30D/BN MCs)的最佳工艺,并对微囊进行相关表征。方法采用复凝聚法制备SA/RS 30D/BN MCs,以包封率和载药量为考察指标,采用单因素法考察冰片、可溶性淀粉、Tween 80、海藻酸钠(SA)溶液、Eudragit RS 30D和CaCl2溶液的质量浓度对微囊质量的影响;在此基础上,以包封率为考察指标,通过L(934)正交试验筛选最佳处方,并对微囊的外观形态、理化性质、体外释放情况及初步稳定性进行评价。结果SA/RS 30D/BN MCs最佳处方为:冰片、可溶性淀粉、Tween 80、SA溶液、Eudragit RS 30D、CaCl2溶液的质量浓度分别为3.33%、0.17%、0.17%、1.00%、5.00%、1.50%,微囊的平均包封率为(94.18±0.47)%,平均载药量为(30.42±0.17)%,在初步稳定性试验中微囊中冰片保留率高达92.2%,表征结果表明成功制备了具有缓释性能的冰片微囊。结论采用复凝聚法以海藻酸钠、Eudragit RS 30D为复合囊材制备的冰片微囊可以显著提高冰片的稳定性且具有一定的缓释效果。
Objective To study the optimal process for preparing borneol microcapsules with sodium alginate and Eudragit RS 30D(SA/RS 30D/BN MCs),and carry out related characterization.Methods The SA/RS 30D/BN MCs was prepared by complex coacervation method.The effects of mass concentrations of borneol,soluble starch,Tween 80,sodium alginate(SA)solution,Eudragit RS 30D and CaCl2 solution on the quality of microcapsules were investigated by the single factor method with encapsulation rate and drug loading capacity as the assessment indicators.Then,the optimal formulation was screened by L9(34)orthogonal test with the encapsulation rate as the assessment indicator.The appearance,physical and chemical properties,in vitro release behavior,preliminary stability of the optimal formulation was evaluated.Results The optimal of SA/RS 30D/BN MCs was as follows:borneol,soluble starch,Tween 80,sodium alginate,Eudragit RS 30D,CaCl2 with mass concentrations of 3.33%,0.17%,0.17%,1.00%,5.00%,1.50%,respectively.The average encapsulation rate was(94.18±0.47)%and the drug loading was(30.42±0.17)%.In the preliminary stability test,the retention rate of borneol in the microcapsules reached 92.2%,and the characterization results showed that borneol microcapsules with sustained release performance were successfully prepared.Conclusion The borneol microcapsules prepared by complex coacervation method with sodium alginate and Eudragit RS 30D as composite capsules can significantly improve the stability of borneol and have a certain sustained release effect.
作者
方淑冰
林琳
邓彩怡
黄华
陈媛
高皓诗
郭波红
FANG Shubing;LIN Lin;DENG Caiyi;HUANG Hua;CHEN Yuan;GAO Haoshi;GUO Bohong(School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China)
出处
《广东药科大学学报》
CAS
2024年第2期83-90,共8页
Journal of Guangdong Pharmaceutical University
基金
国家自然科学基金项目(82304413)
广东药科大学“创新强校工程”资助项目[广东省大学生创新创业训练计划(202310573036)]。
