摘要
目的:探讨辛伐他汀联合胺碘酮治疗老年心力衰竭合并心房颤动的效果。方法:选取2021年8月—2022年12月西宁市第二人民医院心内科收治的102例老年心力衰竭合并心房颤动患者作为研究对象。根据抛硬币法分为观察组和对照组,各51例。对照组予以胺碘酮单药治疗,观察组在对照组基础上联合辛伐他汀治疗。比较两组实验室指标、心功能、临床治疗效率、心房颤动转复率、不良反应发生率。结果:治疗前,两组C反应蛋白(CRP)、血清总胆固醇(TC)、低密度脂蛋白(LDL-C)水平比较,差异无统计学意义(P>0.05);治疗后,对照组CRP、TC低于治疗前,观察组CRP、TC、LDL-C低于治疗前及对照组,差异有统计学意义(P<0.05)。治疗前,两组左室射血分数(LVEF)、左心房内径(LAD)水平比较,差异无统计学意义(P>0.05);治疗后,对照组LVEF高于治疗前,观察组LVEF高于治疗前及对照组,LAD低于治疗前及对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率和心房颤动转复率均高于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为5.88%;低于对照组的11.76%,但两组间比较,差异无统计学意义(χ^(2)=1.097,P>0.05)。结论:应用辛伐他汀联合胺碘酮治疗老年心力衰竭合并心房颤动的效果较好,可以改善患者心功能,减轻炎症状态,缓解症状,安全性较高。
Objective:To investigate the effect of Simvastatin combined with Amiodarone in the treatment of elderly heart failure complicated with atrial fibrillation.Method:A total of 102 elderly patients with heart failure and atrial fibrillation admitted to the Department of Cardiology of the Second People's Hospital of Xining City from August 2021 to December 2022 were selected as the study objects.They were divided into observation group and control group by coin toss,with 51 cases in each group.The control group was treated with Amiodarone monotherapy,and the observation group was treated with Simvastatin on the basis of control group.The laboratory indexes,cardiac function,clinical treatment efficiency,atrial fibrillation relapse rate and incidence of adverse reactions were compared between the two groups.Result:Before treatment,there were no significant differences in the levels of C-reactive protein(CRP),serum total cholesterol(TC)and low density lipoprotein(LDL-C)between the two groups(P>0.05).After treatment,CRP and TC in control group were lower than those before treatment,and CRP,TC and LDL-C in observation group were lower than those before treatment and control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in left ventricular ejection fraction(LVEF)and left atrial inner diameter(LAD)between the two groups(P>0.05).After treatment,LVEF in control group was higher than that before treatment,LVEF in observation group was higher than that before treatment and control group,LAD was lower than that before treatment and control group,the differences were statistically significant(P<0.05).The total effective rate and atrial fibrillation recurrence rate in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.88%,which was lower than 11.76%in the control group,but there was no significant difference between the two groups(χ^(2)=1.097,P>0.05).Conclusion:Simvastatin combined with Amiodarone is effective in the treatment of senile heart failure complicated with atrial fibrillation,which can improve the heart function of patients,reduce inflammation,relieve symptoms,and have high safety.
作者
王芳
WANG Fang(The Second People's Hospital of Xining City,Xining 810000,China)
出处
《中外医学研究》
2024年第4期50-54,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
心力衰竭
心房颤动
老年
辛伐他汀
胺碘酮
Heart failure
Atrial fibrillation
Elderly
Simvastatin
Amiodarone
