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Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

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摘要 Alcohol consumption contributes to global mortality and cancer development.Acetaldehyde(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA adducts.ACE can be detoxified to acetate by acetaldehyde dehydrogenase type 2(ALDH2).ALDH2 deficiency can lead to ACE accumulation and DNA damage.
出处 《Genes & Diseases》 SCIE CSCD 2024年第3期144-147,共4页 基因与疾病(英文)
基金 supported by grants from the National Nature Science Foundation of China(No.82172565,81620108022,81872245,91129303,991729302,81572759,,31900441,82003069,82103571,882002941,82072570,91129733,81502702).
关键词 MORTALITY DAMAGE ALDH2
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