摘要
采用中红外(MIR)光谱研究地塞米松棕榈酸酯的分子结构。试验发现,地塞米松棕榈酸酯分子结构的MIR吸收模式主要包括游离O-H基团伸缩振动模式(ν_(O-H-游离-MIR))、缔合O-H基团伸缩振动模式(ν_(O-H-缔合-MIR))、RC=CH基团C-H伸缩振动模式(ν_(C-H-MIR))、CH_(2)基团不对称伸缩振动模式(ν_(asCH_(2)-MIR))、CH_(2)基团对称伸缩振动模式(ν_(sCH_(2))-MIR)、C=O基团伸缩振动模式(ν_(C=O-MIR))、RC=CH基团C=C伸缩振动模式(ν_(RC=CH-MIR))、CH_(2)基团变角振动模式(δ_(CH_(2)-MIR))、CH_(3)基团对称变角振动模式(δsCH_(3)-MIR)、C-O基团伸缩振动模式(ν_(C-O-MIR))、C-F基团伸缩振动模式(ν_(C-F-MIR))和CH_(2)基团面内摇摆振动模式(ρCH_(2)-MIR)。采用近红外(NIR)光谱进一步开展地塞米松棕榈酸酯分子结构的研究。试验发现,地塞米松棕榈酸酯分子结构的NIR吸收模式主要包括游离O-H基团伸缩振动倍频模式(ν_(1-NIR))、缔合O-H基团伸缩振动倍频模式(ν_(2-NIR))、CH_(2)基团对称伸缩振动倍频模式(ν_(3-NIR))、C=O基团伸缩振动倍频模式(ν_(4-NIR))、CH_(2)基团不对称伸缩振动和CH_(2)基团对称伸缩振动的合频模式(ν_(5-NIR))。MIR-NIR光谱联用技术可以有效开展地塞米松棕榈酸酯分子结构的研究。
The molecular structure of dexamethasone palmitate was studied using mid infrared(MIR)spectroscopy.The experiment found that the infrared absorption mode of dexamethasone palmitate molecular structure mainly includes free O-H group stretching vibration mode(ν_(O-H-free-MIR)),associated O-H group stretching vibration mode(ν_(O-H-associated-MIR)),RC=CH group C-H stretching vibration mode(ν_(CH-MIR)),CH_(2)group asymmetric stretching vibration mode(ν_(asCH_(2)-MIR)),CH_(2)group symmetric stretching vibration mode(ν_(sCH_(2))-MIR),C=O group stretching vibration mode(ν_(C=O-MIR)),RC=CH group C=C group stretching vibration mode(ν_(C=C-MIR)),CH_(2)group bending vibration mode(δ_(CH_(2)-MIR)),CH_(3)group symmetric bending vibration mode(δ_(sCH_(3)-MIR)),C-O group stretching vibration mode(ν_(C-O-MIR)),C-F group stretching vibration mode(ν_(C-F-MIR))and CH_(2)group rocking vibration mode(ρCH_(2)-MIR).The molecular structure of dexamethasone palmitate was further studied using near-infrared(NIR)spectroscopy.The experiment found that the NIR absorption mode of the molecular structure of dexamethasone palmitate mainly includes the free OH groups stretching vibration frequency doubling mode(ν_(1-NIR)),associated OH group tretching vibration frequency doubling mode(ν_(2-NIR)),CH_(2)symmetric stretching vibration frequency doubling mode(ν_(3-NIR)),C=O group stretching vibration frequency doubling mode(ν_(4-NIR)),the combined frequency mode of CH_(2)group asymmetric stretching vibration and CH_(2)group and symmetric stretching vibration(ν_(5-NIR)).The MIR-NIR spectroscopy combined technology can effectively carry out molecular structure research on dexamethasone palmitate.
作者
杜林楠
孔晓美
雷晓静
柴嘉欣
吉一帆
赫士博
刘晴晴
于宏伟
DU Linnan;KONG Xiaomei;LEI Xiaojing;CHAI Jiaxin;JI Yifan;HE Shibo;LIU Qingqing;YU Hongwei(Shijiazhuang University,College of Chemical Technology,Shijiazhuang 050035,China;Hebei University of Science&Technology School of Chemical and Pharmaceutical Engineering,Shijiazhuang 050018,China;Anesthetic Technology Innovation Center of Hebei Province,Shijiazhuang 050035,China)
出处
《有机氟工业》
CAS
2024年第1期10-14,共5页
Organo-Fluorine Industry
基金
石家庄市麻醉药技术创新中心项目(石科【2019】34号)
河北省生物制药国际联合中心项目(冀科外函【2022】3号)。
关键词
地塞米松棕榈酸酯
中红外光谱
近红外光谱
结构
dexamethasone palmitate
mid infrared spectroscopy
near infrared spectroscopy
structure
