摘要
恶性间皮瘤的发生与接触石棉有关, 众多研究者对间皮瘤的分子变化进行了深入分析, 发现其分子特征是染色体改变, 包括染色体重排、基因突变和基因缺失。最近的研究加强了我们对间皮瘤分子表征的认识, 如抑癌基因的靶向突变、差异基因表达、miRNA和信号通路的改变。深入探讨恶性间皮瘤发生发展的相关机制, 对恶性间皮瘤的早期诊断、临床治疗及预后具有重要意义。本文就恶性间皮瘤发病机制及癌变相关分子的研究进展进行综述。
The occurrence of malignant mesothelioma is related to exposure of asbestos.And many researchers have conducted in-depth analysis of the molecular changes of mesothelioma,showed that its molecular characteristics were chromosome changes,including chromosome rearrangement,gene mutation and gene deletion.Recent studies have strengthened our understanding of molecular characterization of mesothelioma,such as targeted mutations of tumor suppressor genes,differential gene expression,changes of miRNA and signal pathways.It is of great significance for the early diagnosis,clinical treatment and prognosis of malignant mesothelioma to explore the pathogenesis and development of malignant mesothelioma.This article reviews the research progress on the pathogenesis and carcinogenesis-related molecules of malignant mesothelioma.
作者
梅雯
张也频
杨晟杰
Mei Wen;Zhang Yepin;Yang Shengjie(Department of Pathology,The People's Hospital of Chuxiong Yi Autonomous Prefecture,Chuxiong 675000,China;Department of Thoracic Surgery,The Fourth Affiliated Hospital of Dali University,Chuxiong 675000,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2024年第3期232-240,共9页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
国家自然科学基金项目(82160516)
云南省教育厅科学研究基金项目(2022J0716)
云南省地方本科高校基础研究联合专项(202301BA070001-26、202301BA070001-027)。
