摘要
运用硅胶柱色谱、Sephadex LH⁃20、ODS、MCI和半制备高效液相等多种色谱技术对异型南五味子Kadsura heteroclita根二氯甲烷部位的化学成分进行研究。运用NMR、MS、UV、X⁃ray单晶衍射等技术对化合物进行结构鉴定,共分离得到20个化合物,分别鉴定为血筒内酯G(1)、mallomacrostin C(2)、3,4⁃seco(24Z)⁃cychmrt⁃4(28),24⁃diene⁃3,26⁃dioic acid 3⁃methyl ester(3)、黑五味子酸(4)、五内酯E甲酯(5)、五味子酸(6)、heteroclic acid(7)、汉黄芩素(8)、(2R,3R)⁃4′⁃甲氧基二氢槲皮素(9)、15,16⁃bisnor⁃13⁃oxo⁃8(17),11E⁃labdadien⁃19⁃oic acid(10)、stigmast⁃4⁃ene⁃6β⁃ol⁃3⁃one(11)、补骨脂素(12)、(1R,2R,4R)⁃trihy⁃droxy⁃p⁃menthane(13)、香草醇(14)、2⁃(4⁃hydroxyphenyl)⁃ethanol(15)、松柏醛(16)、(E)⁃7⁃(4⁃hydroxy⁃3⁃methoxyphenyl)⁃7⁃methylbut⁃8⁃en⁃9⁃one(17)、香草乙酮(18)、香草酸(19)、香草醛(20)。其中化合物1为新的三萜,命名为血筒内酯G,化合物2~3、8~20均为首次从异型南五味子中分离得到。
The dichloromethane fraction of Kadsura heteroclita roots was separated and purified by chromatographic techniques(e.g.,silica gel,Sephadex LH⁃20,ODS,MCI column chromatography)and semi⁃preparative HPLC.Twenty compounds were isola⁃ted from K.heteroclita,and their structures were identified by NMR,MS,UV,and X⁃ray single crystal diffraction techniques.Twenty compounds were isolated from K.heteroclita,which were identified as xuetongdilactone G(1),mallomacrostin C(2),3,4⁃seco(24Z)⁃cychmrt⁃4(28),24⁃diene⁃3,26⁃dioic acid 3⁃methyl ester(3),nigranoic acid(4),methyl ester schizanlactone E(5),schisandronic acid(6),heteroclic acid(7),wogonin(8),(2R,3R)⁃4′⁃O⁃methyldihydroquercetin(9),15,16⁃bisnor⁃13⁃oxo⁃8(17),11E⁃labdadien⁃19⁃oic acid(10),stigmast⁃4⁃ene⁃6β⁃ol⁃3⁃one(11),psoralen(12),(1R,2R,4R)⁃trihydroxy⁃p⁃menthane(13),homovanillyl alcohol(14),2⁃(4⁃hydroxyphenyl)⁃ethanol(15),coniferaldehyde(16),(E)⁃7⁃(4⁃hydroxy⁃3⁃methoxyphenyl)⁃7⁃methylbut⁃8⁃en⁃9⁃one(17),acetovanillone(18),vanillic acid(19)and vanillin(20).Compound 1 is a new compound named xuetongdilactone G.Compounds 2⁃3 and 8⁃20 are isolated from K.heteroclita for the first time.
作者
曾妮
苏维
张琼丹
姚清颖
付港
袁汉文
余黄合
李斌
王炜
ZENG Ni;SU Wei;ZHANG Qiong-dan;YAO Qing-ying;FU Gang;YUAN Han-wen;YU Huang-he;LI Bin;WANG Wei(Traditional Chinese Medicine and Ethnomedicine Innovation&Development International Laboratory,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Department of Periodical Press,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2024年第6期1549-1557,共9页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82074122,82204766,82304878)
湖南中医药大学研究生创新项目(2022CX71)
湖南省教育厅优秀青年项目(21B0394)
湖南省自然科学基金项目(2023JJ40490,2022JJ40318)
湖南中医药大学校级科研基金项目(2022XJZKC018,202202)。
关键词
血筒
异型南五味子
化学成分
三萜
Xuetong
Kadsura heteroclita
chemical constituents
triterpenoids
