摘要
胃神经内分泌癌(gastric neuroendocrine carcinoma,G-NEC)发病率极低。患者确诊时多数已处于晚期,且通常比胃腺癌更具侵袭性,更易发生脉管癌栓、神经侵犯及术后肝转移。目前治疗方法有限且尚未形成统一的规范化方案,导致患者预后较差。随着人类G-NEC的基因组图谱的构建,识别出MYC作为疾病的关键驱动因子,开发小鼠模型来研究其分子和细胞特征,通过大规模的遗传和药理筛选,为理解G-NEC的生物学特性及治疗提供了新的思路。目前对于G-NEC的发病机制、分子生物学特征、临床病理特点及诊治仍缺乏足够的认识,为进一步提升对该疾病的系统认知,本文对国内外文献进行系统总结,旨在为G-NEC的大样本临床基础转化研究提供系统的理论支持。
Gastric neuroendocrine carcinoma(G-NEC)is a rare malignancy,constituting a small percentage of all gastric cancers.G-NEC is typically diagnosed at advanced stages and exhibits more significant invasiveness than gastric adenocarcinoma,with a higher propensity for vascular invasion,nerve infiltration,and postoperative liver metastasis.Current treatment options are limited and lack standardization,leading to a poor prognosis.Recent studies have elucidated the genomic landscape of human G-NEC,identifying MYC as a pivotal oncogenic driver and establishing a murine model to investigate its molecular and cellular characteristics.Genetic and pharmacological screening has yielded novel insights into the biology and therapeutic approaches for G-NEC.Currently,there is a lack of comprehensive knowledge regarding the pathogenesis,molecular biological characteristics,clinical pathology,and diagnosis and treatment of G-NEC.To advance the systematic comprehension of this condition,this article aims to systematically review domestic and international literature,with the goal of offering theoretical support for large-scale clinical translational research on G-NEC.
作者
周凯
王安强
吴艳
李忠武
步召德
Kai Zhou;Anqiang Wang;Yan Wu;Zhongwu Li;Zhaode Bu(Center of Gastrointestinal Cancer,Peking University Cancer Hospital&Institute,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing 100142,China;Department of Pathology,Peking University Cancer Hospital&Institute,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing 100142,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2024年第2期81-85,共5页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:82173151)资助。
关键词
胃神经内分泌癌
发病机制
分子生物学特征
诊疗
gastric neuroendocrine carcinoma(G-NEC)
pathogenesis
molecular biological characteristics
diagnosis and treatment
