摘要
目的探讨低分子肝素钠联合保胎灵在复发性流产患者中的应用价值及对C-反应蛋白(CRP)与血红素加氧酶1(HO-1)的影响。方法选取2020年3月至2022年4月在我院接受治疗的108例复发性流产(RSA)患者作为研究对象,采用随机表法,将患者随机分为联合组(n=54)和传统组(n=54),传统组患者予以低分子肝素(LMWH);联合组患者加用保胎灵。比较两组患者激素水平、凝血功能、细胞相关因子水平、血清水平的变化、妊娠结局及其并发症的发生情况。结果治疗后,两组β-人绒毛膜促性腺激素(β-HCG)、雌二醇(E 2)和孕酮(P)、活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、转化生长因子-β(TGF-β)和白细胞介素-10(IL-10)、HO-1均升高,且联合组高于传统组(P<0.05);两组纤溶酶原激活抑制剂1(PAI-1)、白细胞介素-17(IL-17)、CRP均下降,且联合组低于传统组;联合组流产率显著低于传统组,活产率则明显高于传统组(P<0.05)。两组患者的足月产率比较差异无统计学意义(P>0.05)。联合组分娩周数显著长于传统组(P<0.05);两组患者妊娠并发症比较差异无统计学意义(P>0.05)。结论LMWH联合保胎灵能有效改善RSA患者妊娠期孕激素水平及凝血功能,提升保胎成功率改善妊娠结局,同时可调节细胞平衡,且对并发症无显著影响。
Objective To investigate the application value of low molecular weight heparin sodium combined with Baofeiling in patients with recurrent spontaneous abortion and its effect on C-reactive protein(CRP)and heme oxygenase-1(HO-1).Methods A total of 108 patients with RSA who received treatment in our hospital from March,2020 to April,2022 were selected as the research objects.All patients were randomly divided into the observation group and control group by random table method.The control group was given LMWH,while patients in the observation group were given additional Baotailing.Serological indicators,pregnancy outcomes,pregnancy complications and adverse reactions were compared between the two groups.Results After treatment,levels of human chorionic gonadotropin(β-HCG),estradiol(E 2),progesterone(P),activated partial thromboplastin time(APTT),prothrombin time(PT),transforming growth factor-β(TGF-β),interleukin-10(IL-10)and heme oxygenase-1(HO-1)in the two groups were all increased.And the combined group was higher than the traditional group(P<0.05).Levels of plasminogen activator inhibitor-1(PAI-1),interleukin-17(IL-17)and C-reactive protein(CRP)in the two groups were all decreased,and those in the combined group were lower than those in the traditional group.The abortion rate of the combined group was significantly lower than that of the traditional group,while the live birth rate was significantly higher than that of the traditional group(P<0.05).There was no significant difference in the full-term delivery rate between the two groups(P>0.05).The delivery weeks of the combined group were significantly longer than those of the traditional group(P<0.05).There was no significant difference in pregnancy complications between the two groups(P>0.05).Conclusion LMWH combined with Baotailing can effectively improve the level of progesterone and coagulation function during pregnancy in patients with RSA,which can improve the success rate of tocolysis and pregnancy outcomes,and further regulate cell balance,but has no significant effect on complications.
作者
邱春萍
曹爱娥
钟威达
王婷
QIU Chunping;CAO Ai’e;ZHONG Weida;WANG Ting(Department of Obstetrics and Gynecology,Hainan Obstetrics and Gynecology Hospital Co.,Ltd.Haikou 570000,China;Department of Laboratory Medicine,Hainan Obstetrics and Gynecology Hospital Co.,Ltd.Haikou 570000,China)
出处
《标记免疫分析与临床》
CAS
2024年第2期259-263,275,共6页
Labeled Immunoassays and Clinical Medicine
基金
海南省卫生健康行业科研项目(编号:20A200520)。
关键词
复发性流产
低分子肝素
保胎灵
血栓前状态
Recurrent spontaneous abortion
Low molecular weight heparin
Baotailing
Prethrombotic state
