摘要
目的探讨血清CXC趋化因子配体16(CXCL16)、内皮细胞特异性分子1(ESM-1)水平对脑小血管病(CSVD)患者认知障碍的诊断价值。方法选取2019年10月至2022年10月期间我院收治的131例CSVD患者,根据患者入院时的蒙特利尔认知评估量表(MoCA)评分结果,将CSVD患者分为认知正常组(60例)和认知障碍组(71例)。Spearman法分析血清CXCL16、ESM-1表达水平与MoCA评分的相关性,Logistic回归分析影响CSVD患者发生认知障碍的相关因素,受试者工作特征(ROC)曲线分析血清CXCL16和ESM-1对CSVD患者认知障碍的诊断价值。结果认知障碍组患者血清CXCL16表达水平高于认知正常组,血清ESM-1表达水平低于认知正常组(P<0.05);血清CXCL16表达水平与MoCA评分呈负相关(r=-0.767,P<0.05),血清ESM-1表达水平与MoCA评分呈正相关(r=0.723,P<0.05);认知障碍组年龄≥60岁、有高血压史、脑梗死的患者所占比例高于认知正常组(P<0.05);年龄、高血压史、脑梗死及CXCL16为CSVD患者发生认知障碍的危险因素,ESM-1为保护因素(P<0.05);血清CXCL16、ESM-1以及二者联合诊断CSVD患者发生认知障碍的AUC分别为0.748、0.671、0.851,二者联合检测优于血清CXCL16、ESM-1各自单独检测(Z二者联合-CXCL16=3.284、Z二者联合-ESM-1=4.111,P=0.001、<0.001),对CSVD并发认知障碍具有较高的诊断价值。结论血清CXCL16、ESM-1的表达水平与CSVD并发认知障碍的发生密切相关,二者联合对CSVD并发认知障碍具有较高的诊断价值。
Objective To investigate the diagnostic value of serum CXC chemokine ligand 16(CXCL16)and endothelial cell specific molecule 1(ESM-1)levels in cognitive impairment in patients with cerebral small vessel disease(CSVD).Methods A total of 131 CSVD patients admitted to our hospital from October,2019 to October,2022 were selected for the study.According to the scores of the Montreal Cognitive Assessment Scale(MoCA)at the time of admission,these CSVD patients were grouped into a cognitively normal group(60 cases)and a cognitively impairment group(71 cases).Spearman method was applied to analyze the correlation between serum CXCL16,ESM-1 expression levels and MoCA score,Logistic regression was applied to identify the relevant factors affecting cognitive impairment in CSVD patients.Receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum CXCL16 and ESM-1 for cognitive impairment in CSVD patients.Results The serum CXCL16 expression level in patients with cognitive impairment was higher than that in the cognitively normal group,while the serum ESM-1 expression level was lower than that in the cognitively normal group(P<0.05);The expression level of serum CXCL16 was negatively correlated with MoCA score(r=-0.767,P<0.05),while the expression level of serum ESM-1 was positively correlated with MoCA score(r=0.723,P<0.05);The proportions of patients with age≥60 years old,history of hypertension,and cerebral infarction in the cognitive impairment group were higher than those in the cognitive normal group(P<0.05);Age,history of hypertension,cerebral infarction,and CXCL16 were risk factors for cognitive impairment in CSVD patients,while ESM-1 was a protective factor(P<0.05);AUCs of cognitive impairment in CSVD patients diagnosed with serum CXCL16,ESM-1,and their combination were 0.748,0.671,and 0.851,respectively,while the combined detection of these two markers was superior to the individual detection of serum CXCL16 or ESM-1(Z combination-CXCL16=3.284,Z combination-ESM-1=4.111,P=0.001,<0.001),suggesting a high diagnostic value for cognitive impairment in CSVD.Conclusion Expression levels of serum CXCL16 and ESM-1 are closely related to the occurrence of cognitive impairment in CSVD,and their combination has a high diagnostic value for cognitive impairment in CSVD.
作者
薛孟霞
王依宁
寻志杰
靳世英
杨艳娟
XUE Mengxia;WANG Yining;XUN Zhijie;JIN Shiying;YANG Yanjuan(Department of Neurology,the First Hospital of Handan,Handan 056000,China;Department of Functional,the First Hospital of Handan,Handan 056000,China)
出处
《标记免疫分析与临床》
CAS
2024年第2期276-281,共6页
Labeled Immunoassays and Clinical Medicine
基金
邯郸市科学技术研究项目(编号:21422083060)。
关键词
CXC趋化因子配体16
内皮细胞特异性分子1
脑小血管病
认知障碍诊断价值
CXC chemokine ligand 16
Endothelial cell specific molecule 1
Cerebral small vessel disease
Cognitive impairment
Diagnostic value
