摘要
目的:观察促性腺激素释放激素激动剂(GnRHa)联合腹腔镜手术治疗子宫内膜异位症(EMT)患者的效果。方法:选取2021年1月至2022年5月该院妇产科收治的106例EMT患者进行前瞻性研究,按随机数字表法将其分为对照组(n=53)和观察组(n=53)。对照组采用腹腔镜手术治疗,观察组在对照组基础上联合GnRHa治疗,比较两组临床疗效、治疗前后卵巢功能指标[雌二醇(E2)、促黄体生成素(LH)、卵泡刺激素(FSH)]水平、治疗期间不良反应发生率,以及术后随访12个月的痛经率和妊娠率。结果:观察组治疗总有效率为90.57%(48/53),高于对照组的75.47%(40/53),差异有统计学意义(P<0.05);治疗后,两组E2、LH和FSH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);随访12个月,观察组痛经率低于对照组,妊娠率高于对照组,差异均有统计学意义(P<0.05)。结论:GnRHa联合腹腔镜手术治疗EMT患者可提高治疗总有效率和妊娠率,降低卵巢功能指标水平和痛经率,效果优于单纯腹腔镜手术治疗。
Objective:To observe effects of gonadotropin releasing hormone agonist(GnRHa)combined with laparoscopic surgery in treatment of patients with endometriosis(EMT).Methods:A prospective study was conducted on 106 patients with EMT admitted to the department of obstetrics and gynecology of the hospital from January 2021 to May 2022.They were divided into control group(n=53)and observation group(n=53)by using the random number table method.The control group was treated with laparoscopic surgery,while the observation group was treated with GnRHa on the basis of that of the control group.The clinical efficacy,the ovarian function indexes[estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)]levels before and after the treatment,the incidence of adverse reactions during treatment,and the dysmenorrhea rate and the pregnancy rate after 12 months of follow-up were compared between the two groups.Results:The total effective rate of the observation group was 90.57%(48/53),which was higher than 75.47%(40/53)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of E2,LH and FSH in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 12 months of follow-up,the dysmenorrhea rate of the observation group was lower than that of the control group,the pregnancy rate was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusions:GnRHa combined with laparoscopic surgery in the treatment of the EMT patients can improve the total effective rate and the pregnancy rate,and reduce the levels of ovarian function indexes and the dysmenorrhea rate.Moreover,it is superior to single laparoscopic surgery.
作者
张璐
刘爱珍
ZHANG Lu;LIU Aizhen(Department of Obstetrics and Gynecology of Zhengzhou Maternal and Child Health Hospital,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2024年第7期75-77,共3页
Medical Journal of Chinese People’s Health
基金
2022年度河南省医学科技攻关计划联合共建项目(LHGJ20220884)。
