摘要
目的探讨维生素D水平与亚急性甲状腺炎(SAT)预后的相关性。方法回顾性分析2020年3月至2022年3月170例SAT患者(SAT组)和86例健康体检者(对照组)的临床资料,对比25-羟基维生素D[25(OH)D]水平并进行分析。数据分析用SPSS 26.0软件。甲状腺功能检测值、血清检测值等计量资料以(x±s)表示,行独立样本t检验;计数资料以[例(%)]表示,采用χ^(2)检验分析。P<0.05为差异有统计学意义。结果SAT组患者的红细胞沉降率(ESR)、C反应蛋白(CRP)、白细胞计数(WBC)、游离三碘甲腺原氨酸(FT3)及游离甲状腺素T4(FT4)值均高于对照组(P<0.001),25(OH)D、TSH值低于正常对照组(P<0.001);26例复发患者的25(OH)D水平为(12.8±1.6)ng/ml,低于非复发患者的(14.2±1.9)ng/ml,差异有统计学意义(P=0.017)。170名SAT患者治疗后永久性甲状腺功能减退17例(10.0%),但与非甲减患者25(OH)D水平差异无统计学意义(P=0.71)。结论亚急性甲状腺炎治疗后复发患者的维生素D水平明显低于非复发患者,说明可针对性补充降低其复发率。
Objective To investigate the correlation between vitamin D level and prognosis of subacute thyroiditis(SAT).Methods The clinical data of 170 SAT patients(SAT group)and 86 healthy subjects(control group)from March 2020 to March 2022 were retrospectively analyzed,and the 25-hydroxyvitamin D[25(OH)D]levels were compared and analyzed.SPSS 26.0 software was used for data analysis.Measurement data such as thyroid function test value and serum test value were expressed as(x±s),and independent sample t test was performed.The statistical data were represented by[example(%)]andχ^(2) analysis was used.P<0.05 was considered statistically significant.Results The values of erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),white blood cell count(WBC),free triiodothyronine(FT3)and free thyroxine T4(FT4)in SAT group were higher than those in control group(P<0.001),and the values of 25(OH)D and TSH were lower than those in normal control group(P<0.001).The 25(OH)D level of 26 patients with relapse was(12.8±1.6)ng/ml,which was lower than that of non-relapse patients(14.2±1.9)ng/ml,and the difference was statistically significant(P=0.017).Among 170 SAT patients,17(10.0%)had permanent hypothyroidism after treatment,but there was no significant difference in 25(OH)D level between SAT and non-hypothyroidism patients(P=0.71).Conclusion The level of vitamin D in patients with recurrent subacute thyroiditis after treatment is significantly lower than that in non-recurrent patients,indicating that targeted supplementation can reduce the recurrence rate.
作者
张秋子
胡利梅
陈雅茹
左丽
任卫东
Zhang Qiuzi;Hu Limei;Chen Yaru;Zuo Li ;Ren Weidong(Department of Endocrinology,The First Affiliated Hospital of Hebei North University,Zhangjiakou Hebei Province 075000,China)
出处
《中华普外科手术学杂志（电子版）》
2024年第2期217-219,共3页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
基金
河北省卫生健康委员会科研基金项目(20231417)。
