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妊娠期肝内胆汁淤积症的研究进展

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摘要 妊娠期肝内胆汁淤积症(ICP)是妊娠中晚期常见的并发症。近年研究提示,肠道菌群失衡在ICP的发生和发展过程中发挥了重要作用。ICP可增加妊娠合并症的发生率,如子痫前期、妊娠期糖尿病等,对胎儿造成不良影响;ICP孕妇血清胆汁酸谱分析有助于临床诊断和鉴别诊断;熊去氧胆酸仍然是ICP一线治疗药物,奥贝胆酸是很有潜力的一种药物。
作者 李菊红 邵勇
机构地区 重庆医科大学附属第一医院妇产科 重庆市渝北区妇幼保健院
出处 《肝脏》 2024年第3期348-352,共5页 Chinese Hepatology
基金 国家自然科学基金资助项目(81471473) 重庆市科卫联合医学科研重点项目(2019ZDXM055) 重庆市卫健委中青年医学高端后备人才培养项目(2015XMSB0001298) 重庆市中青年医学高端人才(邵勇)工作室。
关键词 妊娠期肝内胆汁淤积症 胆汁酸谱 奥贝胆酸
分类号 R714.255 [医药卫生—妇产科学]
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