摘要
目的观察锌指蛋白A20(A20)、结缔组织生长因子(connective tissue growth factor,CTGF)在慢性乙型肝炎患者肝脏组织中的表达和定位情况,并检测瞬时肝弹性测定(FibroScan),探讨其与肝脏纤维化的关系。方法对160例来自2017年1月至2020年6月石家庄市第五医院住院患者的慢性乙型肝炎患者,肝组织中的A20、CTGF按照肝脏病理纤维化及炎症分期,行免疫组化定量检测,并检测FibroScan,进行统计学分析。结果肝组织A20、CTGF表达随肝脏病理纤维化及炎症加重而增加,各期与对照组之间差异有统计学意义(P<0.05),相邻组间两两比较差异有统计学意义(P<0.05)。FibroScan亦随肝脏病理纤维化及炎症加重而增加,各期与对照组之间差异有统计学意义(P<0.05),相邻组间两两比较差异无统计学意义(P>0.05)。肝脏A20、CTGF之间呈正相关,r=0.796,(P<0.05)。结论慢性乙型肝炎患者A20、CTGF、FibroScan与肝脏纤维化程度均呈正相关,A20、CTGF亦与肝脏炎症程度正相关,其可作为评价肝脏炎症及纤维化严重程度的指标,进一步指导患者的抗炎抗纤维化的治疗。
Objective Studies on the expression and location of zinc finger protein A20(A20)and connective tissue growth factor(CTGF)in liver tissues of patients with chronic hepatitis B were conducted,and the relationship between them and liver fibrosis was determined by FibroScan.Methods Studies on A20 and CTGF in liver tissues of 160 patients with chronic hepatitis B were conducted in accordance with the stage of pathological fibrosis and inflammation of the liver,and quantitative immunohistochemistry test was conducted,and statistical analysis was conducted by FibroScan.Results The expressions of A20 and CTGF in liver tissues increased with the aggravation of liver pathological fibrosis and inflammation,and there were significant differences between each stage and the control group(P<0.05),and there were significant differences between adjacent groups(P<0.05).Studies have shown that FibroScan increases along with pathological fibrosis and inflammation in the liver.There are significant differences between the stage and the control group(P<0.05),and no significant differences between the adjacent groups(P>0.05).There was positive correlation between liver A20 and CTGF,r=0.796(P<0.05).Conclusions In patients with chronic hepatitis B,A20,CTGF and FibroScan are positively correlated with the degree of liver fibrosis,and A20 and CTGF are also positively correlated with the degree of liver inflammation,which can be used as indicators to evaluate the degree of liver inflammation and fibrosis,and further guide the anti-inflammatory and anti-fibrosis treatment of patients.
作者
张松
赵子龙
胡倩
李健
王晓静
耿惠杰
康海燕
孙殿兴
郭争荣
ZHANG Song;ZHAO Zilong;HU Qian;LI Jian;WANG Xiaojing;GENG Huijie;KANG Haiyan;SUN Dianxing;GUO Zhengrong(Department of Infection Section Six,Shijiazhuang Fifth Hospital,Shijiazhuang,Hebei 050021,China;All-Army Liver Disease Treatment Center,Department of Liver Diseases,Ninth 80th Hospital of the People′s Liberation Army,Shijiazhuang,Hebei 050021,China;Department of Gastroenterology,Shijiazhuang People′s Hospital,Shijiazhuang,Hebei 050012,China)
出处
《公共卫生与预防医学》
2024年第3期133-136,共4页
Journal of Public Health and Preventive Medicine
基金
河北省2022年度医学科学研究课题计划(20221685)。
