摘要
浆细胞样树突状细胞是一种具有独特免疫效应的细胞,其在机体的免疫防御过程中发挥着重要作用,但同时也可能促进疾病的发展并对机体造成损伤。近年来浆细胞样树突状细胞的生物学特性、免疫学功能、在某些肿瘤和自身免疫性疾病中的致病机制以及相关的免疫治疗已经得到了广泛的关注。本文将对这些研究进行综述,以深入探讨浆细胞样树突状细胞在机体中的作用,并为相关疾病的治疗提供新的思路。
Plasmacytoid dendritic cells,a distinctive subset within the dendritic cell family,exhibit a unique immunological profile,in that they are pivotal in the body's immune defense,but interestingly,they can also contribute to disease progression and cause potential harm.Recent years have seen a surge in research exploring the intricate biological characteristics,immunological functions and pathogenic mechanisms of plasmacytoid dendritic cells,especially in the context of tumors and autoimmune disorders.Furthermore,immunotherapies targeting plasmacytoid dendritic cells have also garnered significant attention.This review aimed to delve deeper into the dualistic nature of plasmacytoid dendritic cells,shedding light on their precise mechanisms and ultimately paving the way for novel treatments in related pathological diseases.
作者
尹建运
董庆华
苏杭
黄莉
倪倩
Yin Jianyun;Dong Qinghua;Su Hang;Huang Li;Ni Qian(Pediatric Respiratory Department,The Second Hospital of Lanzhou University,Lanzhou 730030,China)
出处
《兰州大学学报（医学版）》
2024年第2期80-86,共7页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省自然科学基金资助项目(22JR5RA986,22JR5RA1006)
兰州大学第二医院“萃英科技创新”计划资助项目(CY2020-MS13)。
