摘要
目的探讨产前母体血清甲胎蛋白(AFP)、游离β绒毛膜促性腺激素(Free-β-HCG)、雌三醇(uE3)检测对筛查胎儿染色体异常的临床价值。方法选取我院2021年9月—2023年3月100例高风险孕妇进行无创DNA检测,根据染色体状态分为阳性组、阴性组。对比2组孕12周时血清AFP、Freeβ-HCG、uE3及NT值水平,Logistic回归分析血清各指标对胎儿染色体异常的影响因素;ROC分析孕12周时血清各指标联合检测对胎儿染色体异常的预测价值。结果阳性组孕12周时血清AFP、uE3均低于阴性组、血清Freeβ-HCG及NT值均高于阴性组(P<0.05);分析认为孕12周时血清AFP、uE3为胎儿染色体异常的保护因素、Freeβ-HCG及NT值为胎儿染色体异常的危险因素(P<0.05);ROC分析孕12周时检测母体血清AFP、Freeβ-HCG、uE3水平对预测胎儿染色体异常的AUC分别为0.654、0.673、0.664,其联合检测对预测胎儿染色体异常的AUC为0.717。结论产前母体血清AFP、Freeβ-HCG、uE3联合检测在胎儿染色体异常的筛查中均具有较高的预测价值,3者联合检测的预测效能更高,可广泛应用于早期临床筛查中。
Objective To investigate the clinical value of maternal serum alpha-fetoprotein(AFP),free-beta-human chorionic gonadotropin(Free-β-HCG),and uniparental disomy(uE3)detection for screening fetal chromosomal abnormalities.Methods A total of 100 high-risk pregnant women in our hospital from September 2021 to March 2023 were selected for non-invasive DNA detection,and were divided into positive group and negative group according to chromosome status.The levels of serum AFP,Freeβ-HCG,uE3 and NT were compared between the two groups at 12 weeks of pregnancy,and the influencing factors of serum indexes on fetal chromosome abnormality were analyzed by Logistic regression.Diagnostic value of serum indexes combined with ROC analysis for fetal chromosomal abnormalities at 12 weeks of pregnancy.Results At 12 weeks of pregnancy,serum AFP and uE3 in positive group were lower than those in negative group,serum Freeβ-HCG and NT values were higher than those in negative group(P<0.05).At 12 weeks of pregnancy,serum AFP and uE3 were protective factors of fetal chromo-some abnormality,and Freeβ-HCG and NT were risk factors of fetal chromosome abnormality(P<0.05).The AUCs of maternal serum AFP,Freeβ-HCG,and uE3 levels for predicting fetal chromosomal abnormalities at 12 weeks of gestation were 0.654,0.673,and 0.664,respective-ly,while the combined detection of these three markers had an AUC of 0.717 for predicting fetal chromosomal abnormalities.Conclusion The combined detection of maternal serum AFP,Freeβ-HCG,and uE3 in prenatal screening has high predictive value for fetal chromosomal abnor-malities,and the combined detection of the three has higher predictive efficiency and can be wide-ly used in early clinical screening.
作者
王玉敏
杨可可
张卫云
Wang Yumin;Yang Keke;Zhang Weiyun(Prenatal Diagnosis Laboratory of Zhoukou Maternal and Child Health Hospital(Zhoukou Children's Hospital),Zhoukou,Henan 466000,China;Laboratory Department of Zhoukou Maternal and Child Health Hospital(Zhoukou Children's Hospital),Zhoukou,Henan 466000,China)
出处
《青岛医药卫生》
2024年第2期113-116,共4页
Qingdao Medical Journal
