摘要
目的:探讨促代谢因子(Betatrophin)、血管生成素样蛋白4(ANGPTL4)联合预测妊娠期糖尿病(GDM)患者不良妊娠结局价值。方法:回顾性收集2019年10月-2022年9月本院分娩的GDM患者128例为GDM组、健康孕妇128例为对照组,比较两组血清Betatrophin、ANGPTL4水平及妊娠结局。logistic回归分析GDM患者不良妊娠结局的影响因素;受试者工作特征(ROC)曲线分析血清Betatrophin、ANGPTL4对GDM患者妊娠结局的预测价值。结果:GDM组血清Betatrophin水平(390.27±65.05pg/ml)及不良妊娠结局发生率(34.4%)高于对照组(291.56±48.59pg/ml、8.6%),ANGPTL4水平(4.23±1.40 ng/ml)低于对照组(8.22±2.74 ng/ml),GDM妊娠结局不良组糖尿病家族史占比、血清Betatrophin水平高于结局良好组,ANGPTL4水平低于妊娠结局良好组,糖尿病家族史、Betatrophin较高、ANGPTL4较低是GDM患者不良妊娠结局的危险因素(均P<0.05)。血清Betatrophin、ANGPTL4预测GDM患者不良妊娠结局的曲线下面积(AUC)分别为0.864、0.877,联合预测AUC(0.968)提高,其灵敏度97.7%、特异度85.7%。结论:GDM患者血清Betatrophin水平较高、ANGPTL4水平较低,是不良妊娠结局发生危险因素,2项指标联合检测预测GDM患者不良妊娠结局价值较好。
Objective:To explore the value of the combined levels of betatrophin and angiopoietin like protein 4(ANGPTL4)of pregnant women with gestational diabetes mellitus(GDM)for predicting their pregnancy outcomes.Meth-ods:A total of 128 pregnant women with GDM delivered in hospital from October 2019 to September 2022 were collected in study group retrospectively,128 healthy pregnant women who delivered in hospital were collected in control group during the same period.The serum betaprophin and ANGPTL4 levels,and the pregnancy outcomes of the women were compared between the two groups.The influencing factors of the adverse pregnancy outcomes of the women in the study group were analyzed by logistic regression analysis.The predictive values of the levels of serum Betaprophin and ANGPTL4 of the women with GDM for their pregnancy outcomes were analyzed by receiver operator characteristic(ROC)curve.Results:The serum betatrophin level(390.27±65.05 pg/ml)and the incidence of adverse pregnancy outcomes(34.4%)of the women in the study group were significantly higher than those(291.56±48.59 pg/ml and 8.6%)of the women in the control group.The level of ANGPTL4(4.23±1.40ng/ml)of the women in the study group was significantly lower than that(8.22±2.74 ng/ml)of the women in the control group.The proportion of the family history of diabetes and the serum betatrophin level of the women with GDM and adverse pregnancy outcomes were significantly higher than those of the women with GDM and normal pregnancy outcomes,and the level of ANGPTL4 of the women with GDM and adverse pregnancy outcomes was significantly lower.The family history of diabetes,the higher betatrophin level and the lower ANGPTL4 level of the women with GDM were the risk factors of their adverse pregnancy outcomes(all P<0.05).The area under the curve(AUC)of the serum betatrophin level and the ANGPTL4 level of the women with GDM for predicting their adverse pregnancy outcomes were 0.864 and 0.877.The AUC,the sensitivity and the specificity of the combined levels of betatrophin and ANGPTL4 of the women with GDM for predicting their adverse pregnancy outcomes were 0.968,97.7% and 85.7%,respectively.Conclusion:The level of serum betaprophin of the women with GDM is higher and the level of serum ANGPTL4 is lower,and both of which are the risk factors of the adverse pregnancy outcomes of the women.The combined levels of betatrophin and ANGPTL4 of the women with GDM has better value for predicting their pregnancy outcomes.
作者
梅茹
张昌清
MEI Ru;ZHANG Changqing(Shiyan Maternal and Child Health Care Hospital,Shiyan,Hubei Province,442000)
出处
《中国计划生育学杂志》
2024年第4期861-865,共5页
Chinese Journal of Family Planning
基金
湖北省卫生健康委员会科研项目(WJ2021F055)。
