摘要
目的 探究阿米卡星、异烟肼支气管介入联合四联抗结核对支气管结核患者病灶吸收、炎症反应的影响。方法 选取2020年3月至2022年3月周口市传染病医院收治的80例支气管结核患者,采用随机数表法分为两组,每组各40例,对照组采用四联抗结核联合阿米卡星治疗,研究组在对照组的基础上另给予异烟肼支气管介入,比较两组疗效、炎症反应和不良反应情况。结果 治疗6个月,两组治疗有效率比较,研究组高于对照组,差异有统计学意义(P <0.05);两组治疗后降钙素原(PCT)、血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平低于治疗前,且研究组低于对照组,差异有统计学意义(P <0.05);两组不良反应发生情况对比差异无统计学意义(P> 0.05)。结论 阿米卡星、异烟肼支气管介入联合四联抗结核的治疗方案可以促使患者更有效地吸收和清除结核病灶,减轻炎症反应,且不会额外增加不良反应。
Objective To investigate the effects of amikacin and isoniazid bronchial intervention combined with quadruple anti-tuberculosis therapy on lesion absorption and inflammation in patients with bronchial tuberculosis.Methods A total of 80patients with bronchial tuberculosis admitted to our hospital from March 2020 to March 2022 were selected and divided into two groups by random number table method,with 40 cases in each group.The control group was treated with quadruple antituberculosis combined with amikacin,and the research group was additionally given isoniazid bronchial intervention on the basis of the control group,and the absorption efficiency in the lesions was compared between the two groups.The changes of inflammatory factors and the incidence of adverse reactions.Results After 6 months of treatment,the total effective rate of the two groups was higher in the study group than in the control group(P < 0.05);The levels of procalcitonin(PCT),serum tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) in the study group were lower than those before treatment,and lower than those in the control group(P > 0.05);There was no significant difference between adverse reactions between the study group and the control group(P > 0.05).Conclusion Amikacin and isoniazid bronchial intervention combined with quadruple anti-tuberculosis treatment can promote the absorption and clearance of tuberculosis lesions in patients more effectively,reduce inflammation,and maintain high safety.
作者
李美荣
王伟
LI Meirong;WANG Wei(Department of Tuberculosis,Zhoukou Infectious Diseases Hospital,Zhoukou Henan 466000,China)
出处
《临床研究》
2024年第5期69-71,共3页
Clinical Research
关键词
支气管介入疗法
支气管结核
四联抗结核
疗效
bronchial interventional therapy
bronchial tuberculosis
quadruple antituberculosis
curative effect
