摘要
目的:观察泻白散加减治疗肺癌急性放射性肺炎(肺热炽盛证)患者血清转化生长因子-β1(TGF-β1)、降钙素原(PCT)水平的影响。方法:选取2020年8月至2022年11月我院收治的98例肺癌急性放射性肺炎(肺热炽盛证)患者,随机分为对照组与研究组各49例,对照组给予常规西药治疗,研究组在对照组基础上加用中药泻白散加减治疗,均治疗2周,比较两组患者的临床疗效,中医证候积分(气促、胸痛、咳嗽、咳痰),血氧指标[血氧分压(PaO2)、氧合指数(OI)水平],血清炎性因子指标(血清TGF-β1、PCT水平),生活质量(SF-36生活质量量表评分)以及不良反应发生情况。结果:治疗后,研究组患者的总有效率为93.88%高于对照组的75.51%(P<0.05);研究组患者的气促、胸痛、咳嗽、咳痰等中医证候积分均低于对照组(P<0.05);研究组患者的PaO2、OI水平均高于对照组(P<0.05);研究组患者的血清TGF-β1、PCT水平均低于对照组(P<0.05);研究组患者的SF-36量表评分优于对照组(P<0.05);两组患者均未见有明显严重不良反应发生且研究组患者的不良反应发生率与对照组比较无统计学差异(P>0.05)。结论:泻白散加减治疗肺癌急性放射性肺炎(肺热炽盛证)患者的疗效较好,可提升疗效,缓解中医证候,改善机体炎性反应,并提高生活质量,安全性好。
Objective:To observe the effects of modified Xiebai Powder on levels of serum transforming growth factor-β1(TGF-β1)and procalcitonin(PCT)in patients with acute radiation pneumonia(ARP)of lung cancer(lung heat exuberance syndrome).Methods:A total of 98patients with ARP of lung cancer(lung heat exuberance syndrome)admitted to the hospital were enrolled and randomly divided into control group and study group between August 2020and November 2022,49cases in each group.The control group was treated with routine western medicine,while study group was additionally treated with modified Xiebai Powder.All were treated for 2weeks.The clinical curative effect,scores of TCM symptoms(shortness of breath,chest pain,cough,expectoration),blood oxygen indexes[oxygen partial pressure(PaO2),oxygenation index(OI)],serum inflammatory factors(serum TGF-β1,PCT),quality of life(SF-36)and occurrence of adverse reactions in the two groups were compared.Results:After treatment,total response rate of study group was higher than that of control group(93.88%vs 75.51%,P<0.05).After treatment,scores of TCM symptoms in study group were lower than those in control group(P<0.05),levels of PaO2 and OI were higher than those in control group(P<0.05),levels of serum TGF-β1and PCT were lower than those in control group(P<0.05),and SF-36score was better than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05),and there were no significant serious adverse reactions in either group.Conclusion:The curative effect of modified Xiebai Powder is good on patients with ARP of lung cancer(lung heat exuberance syndrome),which can improve curative effect,relieve TCM symptoms,improve inflammatory response and quality of life,with good safety.
作者
瞿明奎
杜斌
姜赛赛
李慧芳
李玉霞
陈裕民
余胜年
王文彬
QU Mingkui;DU Bin;JIANG Saisai(Respiratory Allergy Department of Huangzhou District People's Hospital,Huanggang Hubei 438000,China)
出处
《四川中医》
2024年第1期100-103,共4页
Journal of Sichuan of Traditional Chinese Medicine
基金
国家卫生健康委“十四五”规划全国重点课题(编号:NHFPC102928)。
关键词
泻白散
肺癌
急性放射性肺炎
肺热炽盛证
疗效
Xiebai Powder
Lung cancer
Acute radiation pneumonia
Lung heat exuberance syndrome
Curative effect
