摘要
目的分析骨桥蛋白(OPN)、富含脯氨酸的酪氨酸激酶2(Pyk2)、细胞外信号调节激酶(ERK)、基质金属蛋白酶-9(MMP-9)在舌癌患者癌组织中的表达及其临床意义。方法选取62例舌癌患者,收集其癌组织与癌旁正常组织(距离病灶边缘≥3 cm),分别纳入观察组与对照组,对比2组OPN、Pyk2、ERK、MMP-9的差异。另收集患者的年龄、性别等资料,分析OPN、Pyk2、ERK、MMP-9与患者各项临床病理特征的关系。结果观察组OPN、Pyk2、ERK、MMP-9阳性表达率高于对照组,差异有统计学意义(P<0.05)。OPN、Pyk2、ERK、MMP-9表达与舌癌患者的年龄、性别、肿瘤直径无关(P>0.05),与临床分期、分化程度、淋巴结转移有关(P<0.05)。结论OPN、Pyk2、ERK、MMP-9在舌癌患者的癌组织内呈异常的高表达,且与肿瘤的临床分期、分化程度、淋巴结转移具有紧密联系。
Objective To analyze the expression and clinical significance of osteopontin(OPN),proline rich tyrosine kinase 2(Pyk2),extracellular signal-regulated kinase(ERK),and matrix metalloproteinase-9(MMP-9)in tongue cancer tissue.Methods 62 patients with tongue cancer were selected,and their cancer tissue and adjacent normal tissue(≥3 cm from the edge of the lesion)were collected.They were included in the observation group and the control group respectively,and the differences in OPN,Pyk2,ERK,and MMP-9 between the 2 groups were compared.Collect age,gender and other data of patients,and analyze the relation between OPN,Pyk2,ERK,MMP-9 and various clinical pathological characteristics of patients.Results The positive expression rates of OPN,Pyk2,ERK,and MMP-9 in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).The expression of OPN,Pyk2,ERK,and MMP-9 was not related to age,gender,and tumor diameter of tongue cancer patients(P>0.05),but was related to clinical stage,degree of differentiation,and lymph node metastasis(P<0.05).Conclusion OPN,Pyk2,ERK,and MMP-9 are abnormally high expressed in the cancer tissue of tongue cancer patients,and are closely related to the clinical stage,degree of differentiation,and lymph node metastasis of the patients.
作者
黄小芳
李玉宁
李文鹿
郭琼
HUANG Xiaofang;LI Yuning;LI Wenlu(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第5期710-712,共3页
The Practical Journal of Cancer
关键词
舌癌
癌组织
病理特征
Tongue cancer
Cancer tissue
Pathological characteristics
