摘要
H型高血压是伴有血中同型半胱氨酸(Hcy)升高(血清Hcy浓度≥10μmol/L)的高血压。Hcy与高血压协同增加心脑血管疾病尤其是脑卒中的风险。我国高血压患者中约75%是H型高血压,与我国人群特点密切相关,早期筛查并诊断H型高血压患者,并开展精准防治对降低高血压患者脑卒中风险至关重要。降压基础上补充叶酸可有效降低高血压患者脑卒中风险,不同人群补充叶酸预防脑卒中的效果并不相同,筛查成本获益比更高的人群可明显提高防治效率。随着H型高血压概念的提出,越来越多的学者针对其开展研究,为理解相关机制提供了有价值的线索,有必要开展进一步的深入研究,拓展和补充H型高血压相关理论。
H-type hypertension is accompanied by elevated homocysteine(Hcy)(≥10μmol/L)in the blood,which synergistically increases the risk of cardiovascular diseases with hypertension,especially stroke.Approximately 75%of hypertensive patients in China are H-type,which is closely associated with the characteristics of Chinese population.Early screening and diagnosis of H-type hypertension and accurate prevention and treatment are of significance.Folic acid supplementation based on blood pressure reduction can effectively reduce the risk of stroke in hypertensive patients.The effects of folic acid supplementation on stroke prevention vary among different populations.Screening patients with a higher cost-benefit ratio can significantly improve prevention and treatment efficiency.With the proposal of H-type hypertension concept,more and more related studies have been conducted,which provides valuable clues for elucidating relevant mechanisms.It is necessary to carry out further in-depth research to expand and supplement related theories of H-type hypertension.
作者
范芳芳
霍勇
Fan Fangfang;Huo Yong(Department of Cardiovascular Disease,Peking University First Hospital,Beijing 100034,China)
出处
《新医学》
CAS
2024年第4期243-247,共5页
Journal of New Medicine
基金
国家重点研发计划(2016YFC0903100)
国家自然科学基金(81703288)。
