摘要
目的 探讨外周血纤维蛋白原和中性粒细胞/淋巴细胞比值联合评分(F-NLR)对自发性基底节区脑出血短期预后的预测作用。方法 回顾性分析2021年1月-2022年12月自发性基底节区脑出血患者154例,通过改良Rankin量表(mRS)评分系统进行评估,将患者分成预后良好组(n=50)和预后不良组(n=104)。应用单因素和多因素回归分析基底节区脑出血的风险因素,并利用ROC曲线评估F-NLR在基底节区脑出血预后中的应用价值。结果 2组患者的年龄、血肿体积、是否破入脑室、格拉斯哥昏迷评分(GCS评分)、白细胞(WBC)计数、中性粒细胞(ANC)计数、淋巴细胞(ALC)计数、中性粒细胞/淋巴细胞比值(NLR)、纤维蛋白原(FIB)、F-NLR水平差异有统计学意义(P<0.05)。多元logistic回归分析显示基底节区脑出血患者的血肿体积、GCS评分、高WBC、低ALC、高F-NLR评分是其短期预后不良的重要独立危险因素(P<0.05)。ROC曲线表明F-NLR评分预测基底节区脑出血预后不良的AUC值为0.799(95%CI:0.723~0.874),敏感度为66.3%,特异度为86.0%。结论 F-NLR评分对基底节区脑出血患者的近期预后具有重要指导意义,可作为进一步临床应用的依据。
Objective To investigate the role of the combined peripheral blood fibrinogen and neutrophil/lymphocyte ratio score(F-NLR)in predicting the short-term prognosis of spontaneous basal ganglia hemorrhage.Methods A total of 154 patients with spontaneous basal ganglia hemorrhage who were admitted from January 2021 to December 2022 were enrolled and their clinical data were retrospectively analyzed.The patients were evaluated by the modified Rankin Scale(mRS).According to their prognosis,they were divided into two groups:a good prognosis group(n=50)and a poor prognosis group(n=104).The risk factors for basal ganglia hemorrhage were analyzed by univariate and multivariate regression.A ROC curve was plotted to evaluate the predictive value of F-NLR for the prognosis of patients with basal ganglia hemorrhage.Results There were statistical differences in age,hematoma volume,whether it broke into the ventricle,GCS score,white blood counts,absolute neutrophil count(ANC),absolute lymphocyte count(ALC),neutrophil/lymphocyte ratio(NLR),fibrinogen(FIB),and F-NLR between the two groups(P<0.05).Multivariate logistic regression analysis showed that the hematoma volume of basal ganglia hemorrhage,Glasgow Coma Scale(GCS)score,high WBC,low ALC,and high F-NLR scores were important independent risk factors for poor short-term prognosis for patients with basal ganglia hemorrhage(P<0.05).The ROC curve indicated that the AUC value of F-NLR score for predicting the poor prognosis of basal ganglia hemorrhage was 0.799(95%CI:0.723-0.874),with a sensitivity of 66.3%and a specificity of 86.0%.Conclusions The F-NLR score is an important marker for predicting the prognosis of patients with basal ganglia hemorrhage,which can provide reference for future clinical application.
作者
肖耀东
张啸虎
吴俊逸
夏浩
谢满意
范月超
梁君
XIAO Yaodong;ZHANG Xiaohu;WU Junyi;XIA Hao;XIE Manyi;FAN Yuechao;LIANG Jun(Graduate School,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;Department of Neurosurgery,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221002)
出处
《徐州医科大学学报》
CAS
2024年第3期175-180,共6页
Journal of Xuzhou Medical University
基金
江苏省自然科学基金面上项目(BK20231160)。
