摘要
细胞凋亡及自噬与甲状腺癌的发生发展密切相关,柚皮素、昆布多糖、小白菊内酯、西黄丸、小柴胡汤等多种中药单体及其复方已被证明可通过诱导凋亡、促进自噬抑制甲状腺癌细胞的增殖能力及活性,具有多靶点、多途径、不良反应小等优势,对肿瘤细胞的异质性和多样性更有针对性,为甲状腺癌的临床治疗提供了新路径。但目前相关研究多处于体内及体外实验阶段,临床研究较为匮乏,中药具体分子机制尚未明确,需加强基础实验研究,同时进行多中心、大样本的临床疗效评价,进一步揭示中医药干预甲状腺癌的功效,对甲状腺癌的防治提供更多参考。
Apoptosis and autophagy are closely related to the occurrence and progression of thyroid cancer.A variety of traditional Chinese medicine monomers and their compound formulas such as Naringenin,laminarin,parthenolide,Xi Huang Pill,Xiao Chaihu Decoction,etc.,have been proved to inhibit the proliferative ability and activity of thyroid cancer cells by inducing apoptosis and promoting autophagy,which has the advantages of multi-targets and multi-pathways with small side effect,as well as more targeted to the heterogeneity and diversity of tumor cells to provide a new strategy for treating thyroid cancer.However,at present,relevant studies are mostly in the in vivo or in vitro experimental stage,while clinical studies are scarce.The specific molecular mechanism of TCM has not yet been clarified.In the future,it is urgently needed to strengthen the basic experimental studies,as well as to conduct multi-center and large-sample clinical efficacy evaluations,to confirm the efficacy of TCM in intervening thyroid cancer,which is of great significance in guiding the clinical treatments of thyroid cancer.
作者
王心雨
陈红跃
杨萌萌
李松伟
WANG Xinyu;CHEN Hongyue;YANG Mengmeng;LI Songwei(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Second Affiliated Hospital to Henan University of Chinese Medicine/Henan Provincial Hospital of Chinese Medicine,Zhengzhou Henan China 450002;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2024年第5期986-993,共8页
Acta Chinese Medicine
基金
河南省中医药科学研究专项课题项目(2022ZY2020)。
关键词
甲状腺癌
细胞凋亡
细胞自噬
中医药
thyroid cancer
apoptosis
autophagy
traditional Chinese medicine
