摘要
目的:探讨亚胺培南-西司他丁与莫西沙星联用治疗老年重症肺炎患者对其肝肾功能的影响。方法:选取2020年4月—2023年3月期间在本院进行治疗的100例老年重症肺炎患者,利用患者住院编号的奇偶数,将其分为对照组50例(奇数)和观察组50例(偶数)。对照组使用莫西沙星单药治疗,观察组使用亚胺培南-西司他丁与莫西沙星联合治疗。对2组患者的炎症因子指标、肝功能指标和肾功能指标进行比较。结果:治疗前2组炎症因子差异无统计意义(P>0.05);治疗后2组炎症因子较治疗前明显降低(P<0.05),且观察组C反应蛋白(C-reactive protein,CRP)、白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)均低于对照组(P<0.05);治疗前2组肝功能差异无统计意义(P>0.05);治疗后2组谷丙转氨酶(Alanine aminotransferase,ALT)、谷草转氨酶(Aspartate aminotransferase,AST)、碱性磷酸酶(Alkaline phosphatase,ALP)、总胆红素(Total bilirubin,TBil)均高于治疗前(P<0.05),但2组肝功能差异无统计意义(P>0.05);治疗前2组肾功能差异无统计意义(P>0.05);治疗后2组血肌酐(Serum creatinine,Scr)、尿素氮(Urea nitrogen,BUN)、尿酸(Uric acid,UA)、胱抑素C(Cystatin C,CysC)均高于治疗前(P<0.05),但2组肾功能差异无统计意义(P>0.05);观察组总有效率高于对照组(P<0.05)。结论:对老年重症肺炎患者采用亚胺培南-西司他丁与莫西沙星联合治疗,可有效减轻患者自身炎症反应,对肝肾功能影响较小。
Objective:To investigate the effects of imipenem-cilastatin combined with moxifloxacin on liver and kidney function in elderly patients with severe pneumonia.Methods:A total of 100 elderly patients with severe pneumonia who were treated in our hospital from April 2020 to March 2023 were divided into control group(50 cases)and observation group(50 cases)according to the odd and even hospitalization numbers.The treatment plan was moxifloxacin alone in the control group,and imipenem-cilastatin combined with moxifloxacin in the observation group.The indexes of inflammatory factors,liver function and kidney function were compared between the two groups.Results:There was no significant difference in inflammatory factors between the two groups before treatment(P>0.05).After treatment,serum inflammatory factors in 2 groups were significantly lower than before treatment(P<0.05).In addition,C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the observation group were all lower than those in the control group(P<0.05).There was no significant difference in liver function between the two groups before treatment(P>0.05).After treatment,alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP)and total bilirubin(TBil)in the 2 groups were treated.ALP and TBil were higher than before treatment(P<0.05),but there was no statistical difference in liver function between the two groups(P>0.05).There was no significant difference in renal function between the two groups before treatment(P>0.05).Serum creatinine(Scr),urea nitrogen(BUN),uric acid(UA)and cystatin C(CysC)in 2 groups were all higher than those before treatment(P<0.05).There was no statistical significance in renal function between the two groups(P>0.05).The total effective rate of observation group was higher than that of control group(P<0.05).Conclusion:In elderly patients with severe pneumonia,imipenem-cilastatin combined with moxifloxacin can effectively reduce patients'autoinflammatory response,and has little impact on liver and kidney function.
作者
王涛
WANG Tao(Department of General Medicine,The First People's Hospital of Jiujiang,Jiujiang,Jiangxi 332000)
出处
《赣南医学院学报》
2024年第3期235-238,243,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
