摘要
目的:研究探讨中医药治疗肾性蛋白尿的用药规律,为临床诊疗提供新思路。方法:计算机检索中国知网数据库中有关中医药治疗肾性蛋白尿的文献,检索时间为建库至2023年2月。筛选文献后,将纳入的处方录入Excel中分别进行性味、功效统计,用Origin 2022进行可视化,用SPSS Modeler 18.0对中药进行关联规则分析,挖掘出高频药物,运用SPSS 21.0软件进行聚类分析。结果:共收集到116篇文献,涉及250味中药,出现的频次有1396次。处方中高频药物有黄芪、茯苓、山药、丹参,用药以利水渗湿药、补虚药、收涩药、活血化瘀药为主,药性多为辛、甘、苦,四气以寒、温、平居多。支持度最高的药对为黄芪-山药,常见的药对:黄芪-地龙,黄芪-川芎,黄芪-当归,黄芪-丹参-山药。对高频中药进行聚类分析,共形成四类组方:①芡实、金樱子、杜仲、菟丝子、地龙、蝉蜕、白术、薏苡仁、山茱萸;②熟地黄、牡丹皮、泽泻、茯苓、山药、丹参、生地黄、山茱萸;③党参、石韦;④白花蛇舌草、益母草、当归、川芎、黄芪、赤芍。结论:肾性蛋白尿的病机本质为本虚标实,以脾肾虚为本,兼有瘀血、湿毒,多采用补益脾肾配伍有祛瘀、解毒、利水功效的药物进行治疗,可为临床治疗及临床新药研发提供参考,但仍需进一步验证考究。
Objective:To study and explore the medication rule of TCM medicine in the treatment of renal proteinuria and to provide new ideas for clinical diagnosis and treatment.Methods:The studies about the treatment of renal albuminuria with TCM medicine were searched in CNKI from inception to February 2023.After screening the literature,the included prescriptions were inputted into Excel,and then taste and efficacy statistics were carried out respectively,visualization was carried out by Origin 2022.Association rules of TCM medicine were analyzed by SPSS Modeler 18.0,and then high-frequency drugs were mined,and cluster analysis was carried out by SPSS 21.0 software.Results:A total of 116 articles were collected,involving 250 TCM medicines,with a frequency of 1396.The high-frequency drugs in the prescription are Huangqi(Radix Astragali),Fuling(Poria),Shanyao(Rhizoma Dioscoreae),and Danshen(Radix et Rhizoma Salviae Miltiorrhizae).Drugs for clearing damp and promoting diuresis,drugs for tonifying,drugs for inducing astringency,drugs for promoting blood circulation and removing blood stasis are the main prescription drugs.The medicinal properties are mostly pungent,sweet and bitter.The four Qi(气)are mostly cold,warm and neutral.The drug pair with the highest support is Huangqi-Shanyao.The common drug pairs are:Huangqi-Dilong(Pheretima),Huangqi-Chuanxiong(Rhizoma Chuanxiong),Huangqi-Danggui(Radix Angelicae Sinensis),Huangqi-Danshen-Shanyao.Based on the cluster analysis of high frequency medicine,four kinds of prescriptions were formed.①Qianshi(Semen Euryales),Jinyingzi(Fructus Rosae Laevigatae),Duzhong(Cortex Eucommiae),Tusizi(Semen Cuscutae),Dilong,Chantui(Periostracum Cicadae),Baizhu(Rhizoma Atractylodis Macrocephalae),Yiyiren(Semen Coicis),Shanzhuyu(Fructus Corni).②Shudihuang(Radix Rehmanniae Preparata),Mudanpi(Cortex Moutan),Zexie(Rhizoma Alismatis),Fuling,Shanyao,Danshen,Shengdihuang(Radix Rehmanniae),Shanzhuyu.③Dangsheng(Radix Codonopsis),Shiwei(Folium Pyrrosiae).④Baihuasheshecao(Herba Hedyoti Diffusae),Yimucao(Herba Leonuri),Danggui,Chuanxiong,Huangqi,Chishao(Radix Paeoniae Rubra).Conclusion:The pathogenesis of renal albuminuria is asthenia in origin and excess in superficiality,namely spleen and kidney deficiency,auompanied by blood stasis and damp toxin.The drugs of tonifying spleen and kidney,removing blood stasis,detoxification and clearing damp and promoting diuresis are often used.It can provide reference for clinical treatment and clinical new drug research and development,but it still needs further verification.
出处
《中医临床研究》
2024年第10期81-85,共5页
Clinical Journal Of Chinese Medicine
关键词
中医药
肾性蛋白尿
用药规律
数据挖掘
Traditional Chinese medicine
Renal albuminuria
Medication rule
Data mining
