摘要
目的:分析支气管扩张症(以下简称支扩)合并亚临床动脉硬化性疾病(SAS)患者的高危因素及中医证型分布规律。方法:采用回顾性横断面调查研究方法,选取2021年7月至2022年8月因急性加重就诊于江西中医药大学附属医院的支扩患者157例,根据合并SAS与否分为支扩合并SAS组(91例)和单纯支扩组(66例)。描述两组在一般资料方面的特征,用倾向得分匹配法消除组间混杂因素,Logistic回归模型分析支扩合并SAS的影响因素,并进行中医证型分布规律的探讨。结果:在控制其他因素的条件下,FEV1%pred、FVC%pred、CD4+T、CD8+T可以显著影响支扩合并SAS的发病,为影响支扩合并SAS发病的高危因素。单纯支扩组以实证为主,痰热蕴肺证最常见,占比51.52%(34/66);支扩合并SAS组以虚实夹杂证为主,痰热阻肺兼气阴两虚证最常见,占比42.42%(28/66)。结论:肺通气功能的下降与机体免疫机能的减弱为支扩合并SAS发病的独立危险因素;与单纯支扩相比,支扩合并SAS患者的中医证型更多呈现虚实夹杂的病机特点,痰热阻肺兼气阴两虚证最常见。
Objective:To analyze the high risk factors and the distribution of traditional Chinese medicine(TCM)syndrome types in patients with bronchiectasis with subclinical arteriosclerotic disease(SAS).Methods:A retrospective crosssectional study was conducted,a total of 157 patients with bronchiectasis who were admitted to The Affiliated Hospital of Jiangxi University of Chinese Medicine due to acute exacerbation from July 2021 to August 2022 were selected.According to whether they had SAS or not,they were divided into the bronchiectasis with SAS group(91 cases)and the simple bronchiectasis group(66 cases).Propensity score matching method was used to eliminate confounding factors between groups.Logistic regression analysis was used to analyze the influencing factors of bronchiectasis with SAS,and the distribution of TCM syndrome types was discussed.Results:FEV1%pred,FVC%pred,CD4+T and CD8+T could significantly affect the incidence of bronchiectasis combined with SAS,which were the high risk factors affecting the incidence of bronchiectasis with SAS.The simple bronchiectasis group was mainly based on empirical evidence,and the syndrome of phlegm-heat accumulation in the lung was the most common,accounting for 51.52%(34/66).The bronchiectasis with SAS group was mainly characterized by deficiency and excess syndrome,and the most common syndrome was phum-heat obstruction and deficiency of both lung qi and yin,accounting for 42.42%(28/66).Conclusion:The decrease of pulmonary ventilation function and immune function are independent risk factors for bronchiectasis with SAS.Compared with bronchiectasis alone,the TCM syndrome types of bronchiectasis with SAS are more characterized by the combination of deficiency and excess,and the syndrome of phum-heat obstruction and deficiency of qi and yin is the most common.
作者
尹宝婷
余建玮
李陶
黄帅亮
周妮
YIN Baoting;YU Jianwei;LI Tao;HUANG Shuailiang;ZHOU Ni(Jiangxi University of Chinese Medicine,Nanchang 330004,China;The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2024年第4期2027-2031,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国医大师洪广祥师承工作室,江西省中医药中青年骨干人才项目(No.赣中医药科教字〔2020〕2号)
江西中医药大学校级研究生创新专项(No.JZYC22S44)。
关键词
支气管扩张症
急性加重期
亚临床动脉硬化性疾病
高危因素
中医证型
Bronchiectasis
Acute exacerbation
Subclinical arteriosclerotic disease
High risk factors
Traditional Chinese medicine syndrome types
