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基于D-最优混料设计优选益气固表速溶散处方及评价

Optimal Formulation and Evaluation of Yiqi Gubiao Surong Powder(益气固表速溶散)Based on D-optimal Mixing Design
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摘要 目的综合中药粉体改性技术、矫味技术和原料药前处理技术制备益气固表速溶散,并进行处方优选及评价,解决儿童给药困难的问题。方法在单因素实验的基础上,以流出速度、休止角、吸湿率、粒径分布宽度为评价指标,采用D-最优混料设计优选益气固表速溶散的最佳处方,并通过物理指纹图谱、粉体学性质、口感评价和红外光谱等方法对益气固表速溶散及传统散剂进行评价。结果益气固表速溶散的最佳处方为药辅比5∶1,混料蔗糖-饴糖-柠檬酸比12∶12∶1;3批样品物理指纹图谱相似度均大于0.997,表明3批速溶散的物理质量一致;速溶散和传统散之间的相似度仅为0.129,表明其粉体学性质差异较大,其物理属性有所差异;益气固表速溶散与普通散的粉体学性质及口感存在差异,且速溶散优于传统散;两种散剂的红外光谱基本一致,表明其化学成分结构未发生明显变化。结论益气固表速溶散研制开发能更好地提高儿童用药依从性,为中医临床提供“良药可口”的新选择。 Objective To design and evaluate the children's drug Yiqi Gubiao Surong Powder(益气固表速溶散)by integrating the traditional Chinese medicine powder modification technology,flavor correction technology and raw material drug pretreatment technology,in order to solve the difficulty in swallowing the children's drug.Methods On the basis of single factor experiment,taking outflow velocity,angle of repose,moisture absorption rate and particle size distribution width as evaluation indexes,D-optimal mixing design was used to optimize the optimal formula of Yiqi Gubiao Surong Powder.Fingerprints were used to evaluate the quality consistency of different batches of powders,and compared with traditional powders,Yiqi Gubiao Surong Powder was evaluated by powder properties,taste evaluation and infrared spectroscopy.Results The optimal formula of Yiqi Gubiao Surong Powder was 5∶1 with adjuvant ratio and 12∶12∶1 mixed with sucrose-caramel-citric acid;the similarity of physical fingerprints of the three batches of samples was all greater than 0.997,indicating that the three batches physical quality of instant powder were the same;the similarity between instant powder and traditional powder was only 0.129,indicating that their powder properties were quite different,and their physical properties were different;Yiqi Gubiao Surong Powder and ordinary powder.There were differences in chemical properties and taste,and the instant powder was better than the traditional powder;the infrared spectra of the two powders were basically the same,indicating that the chemical composition structure had not changed significantly.Conclusion The research and development of Yiqi Gubiao Surong Powder can better improve children's medication compliance,and provide a new choice of“good medicine and deliciousness”for clinical Chinese medicine.
作者 辛二旦 于小刚 李东辉 杨新荣 燕玉奎 靳子明 杨锡仓 张兆芳 Erdan;YU Xiaogang;LI Donghui;YANG Xinrong;YAN Yukui;JIN Ziming;YANG Xicang;ZHANG Zhaofang(Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou 730020,Gansu,China;Research Center of Traditional Chinese Medicine of Gansu Provincial,Lanzhou 730030,Gansu,China;YANG Xicang National Famous Traditional Chinese Medicine Expert Inheritance Studio,Lanzhou 730020,Gansu,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730010,Gansu,China)
出处 《辽宁中医药大学学报》 CAS 2024年第5期37-42,共6页 Journal of Liaoning University of Traditional Chinese Medicine
基金 国家自然科学基金项目(82360944) 国家中医药管理局中药炮制技术传承基地建设项目(国中医药规财发[2015]21号) 甘肃省科技厅科技重大专项-中医药产业创新联合体项目(22ZD6FA021-4) 甘肃省中医药研究中心专项开放课题(zyzx-2020-zx25) 杨锡仓全国名老中医药专家传承工作室项目(国中医药人教函[2022]75号) 甘肃中医药大学附属医院科研及技术创新基金项目(gzfy-2021-09)。
关键词 益气固表速溶散 D-最优混料设计 物理指纹图谱 口感评价 红外光谱 Yiqi Gubiao Surong Powder(益气固表速溶散) D-optimal mixture design physical fingerprint taste evaluation infrared spectrum
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