摘要
壳寡糖(Chitooligosaccharide,COS)是几丁质或壳聚糖降解后获得的N-乙酰-D-葡萄糖胺和D-葡萄糖胺的同聚或异聚物,具有抗菌、抗氧化、抗肿瘤、免疫调节等多种生物活性,已被广泛应用于医药、食品、农业等领域。目前,酶法、物理法和化学法均已被报道用于制备COS。然而,单一法制备COS有一定的局限性,很难高效、绿色地获得具有特定聚合度和乙酰度的目标产物。因此,COS的制备已经从单一法转向至协同催化体系的探索。此外,借助超滤法、活性炭吸附法、色谱法等分离纯化技术也可以提高COS的纯度。本文对近年来COS的制备和纯化方法以及应用研究进展进行了综述,以期为高品质COS的生产以及应用领域的拓展提供理论基础。
Chitooligosaccharides(COS)is homo-or heterooligomers of N-acetylglucosamine and D-glucosamine obtained via degradation of chitin or chitosan.COS is useful for remarkably wide spectrum of applications in the pharmaceutical,food,and agricultural industries due in part to their antimicrobial,antioxidant,antitumor,and immunomodulatory activities.Enzymatic,physical,and chemical methods for the preparation of COS has been reported.At present,the preparation of COS by any single method faces limitations,including difficulty in obtaining target products with specific degrees of polymerization and acetylation.Therefore,COS preparation protocols have shifted from single method strategies to explorations of cooperative catalytic systems.COS purity can also be improved by incorporating separation and purification techniques including ultrafiltration,activated carbon adsorption,and chromatography.In this paper,progress in COS preparation and purification methods and COS applications are reviewed,with the objective of providing a theoretical basis for improved production and expansion of applications for high quality COS.
作者
郭汉忠
李永莎
李永成
夏光华
张雪莹
GUO Hanzhong;LI Yongsha;LI Yongcheng;XIA Guanghua;ZHANG Xueying(Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea,Key Laboratory of Seafood Processing of Haikou,National R&D Branch Center for Prawn Processing Technology(Haikou),College of Food Science and Technology,Hainan University,Haikou 570228,China;Collaborative Innovation Center of Provincial and Ministerial Co-Construction for Marine Food Deep Processing,Dalian Polytechnic University,Dalian 116034,China)
出处
《食品工业科技》
CAS
北大核心
2024年第10期412-422,共11页
Science and Technology of Food Industry
基金
海南省自然科学基金项目(320QN203)
海南省自然科学基金项目(322RC587)
海南大学科研启动基金项目(KYQD(ZR)20046)。
关键词
几丁质
壳聚糖
壳寡糖
制备
分离纯化
应用
chitin
chitosan
chitooligosaccharides
preparation
separation and purification
application
