摘要
目的:研究补肾活血汤治疗绝经后骨质疏松症(PMOP)的临床疗效及其作用机制。方法:采用回顾性研究,将120例PMOP患者按治疗方法分为对照组57例和观察组63例。对照组采用基础治疗,观察组在对照组基础上加服补肾活血汤。治疗3个月后,根据腰椎和髋部骨密度(BMD)、骨代谢指标及炎症因子评价2组临床疗效。结果:治疗后,观察组总有效率为80.95%,高于对照组的64.91%,差异有统计学意义(P<0.05)。2组腰椎和髋部BMD、骨钙素(BGP)、Ⅰ型原胶原氨基端延长肽(PINP)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平均高于治疗前,且观察组高于对照组,差异均有统计学意义(P<0.05);2组Ⅰ型胶原羧基端肽β特殊序列(β-CTx)、超敏C反应蛋白(hs-CRP)、趋化因子配体3(CCL3)水平均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论:补肾活血汤治疗PMOP可提高临床疗效,改善患者BMD,其机制可能是通过抑制骨吸收、加快骨形成以及降低炎症反应等发挥作用。
Objective:To explore the clinical efficacy and mechanism of Bushen Huoxue Decoction in the treatment of postmenopausal osteoporosis.Methods:One hundred and twenty patients with postmenopausal osteoporosis were divided into control group(57 cases)and observation group(63 cases)by using retrospective study.The control group was treated with basic treatment,the observation group was given Bushen Huoxue Decoction on the basis of the control group.After 3 months of treatment,the clinical efficacy of the two groups was evaluated according to bone mineral density of lumbar spine and hip,bone metabolism indexes and inflammatory factors.Results:The total effective rate in the observation group was 80.95%,which was higher than that in the control group(64.91%),with statistical significant(P<0.05).Compared with before treatment,the levels of BMD,BGP,PINP,IGFBP-3 were significantly increased in both groups after treatment.The above indexes in the observation group were significantly higher than those in the control group at the same time,with statistical significant(P<0.05).Compared with before treatment,the levels ofβ-CTx,hs-CRP and CCL3 in the two groups were significantly decreased.The above indexes in the observation group were significantly lower than those in the control group,with statistical significant(P<0.05).Conclusion:Bushen Huoxue Decoction can improve the clinical efficacy and BMD of patients with PMOP,which may play a role by inhibiting bone resorption,accelerating bone formation and reducing inflammatory response.
作者
熊润萍
陈静
黄丽君
邓文静
帅品花
XIONG Runping;CHEN Jing;HUANG Lijun;DENG Wenjing;SHUAI Pinhua(The Affiliated Hospital of Jiangxi University of Chinese Medicine,Nanchang 330006,China.)
出处
《江西中医药大学学报》
2024年第2期55-57,共3页
Journal of Jiangxi University of Chinese Medicine
基金
江西省中医药管理局科技计划项目(2020B0030)
江西省卫生计生委中医药科研项目(2018A156,2018A085)。
关键词
补肾活血汤
绝经后骨质疏松症
骨密度
骨代谢
炎症因子
Bushen Huoxue Decoction
Postmenopausal Osteoporosis
Bone Mineral Density
Bone Metabolism
Inflammatory Factors
