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复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛meta分析 被引量:1

Meta-analysis of compound Danshen Dropping Pills combined with isosorbide mononitrate in the treatment of coronary heart disease and angina pectoris
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摘要 目的分析复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛有效性及安全性。方法计算机检索中国知网、维普、万方、PubMed、Web of Science数据库,检索时限为自建库起至2023年2月28日,搜集相关临床随机对照试验(RCT),根据纳排标准选择RCT,使用Review Manager 5.3软件进行meta分析。结果纳入14项RCT,meta分析结果显示,观察组的总有效率[OR=5.01,95%CI(3.39,7.42),P<0.00001]、心绞痛发作次数[MD=-1.75,95%CI(-2.43,-1.07),P<0.00001]、心绞痛发作持续时间[MD=-1.87,95%CI(-2.47,-1.26)、P<0.00001]、总胆固醇[MD=-0.96,95%CI(-1.19,-0.73),P<0.00001]、三酰甘油[MD=-0.52,95%CI(-0.65,-0.40),P<0.00001]、不良反应[OR=0.64,95%CI(0.43,0.97),P=0.03]均优于对照组。结论复方丹参滴丸联合单硝酸异山梨酯+常规西药治疗冠心病心绞痛临床疗效显著,安全性高,但需更多设计严谨的多样本、多中心、双盲RCT提供证据支持。 Objective To evaluate the efficacy and safety of the compound Danshen Dripping Pills combined with isosorbide mononitrate in the treatment of coronary heart disease and angina pectoris.Methods Computer retrieval was conducted on databases such as China National Knowledge Infrastructure(CNKI),VIP,Wanfang,PubMed,and Web of Science.The retrieval duration was from the establishment of the database to February 28,2023.Relevant clinical randomized controlled trial(RCT)were collected,and RCT were selected based on inclusion and exclusion criteria.meta-analysis was conducted using Review Manager 5.3 software.Results 14 RCTs were included,and the meta-analysis results showed the total effective rate(OR=5.01,95%CI[3.39,7.42],P<0.00001),the number of angina pectoris attacks(MD=-1.75,95%CI[-2.43,-1.07],P<0.00001),the duration of angina pectoris attacks(MD=-1.87,95%CI[-2.47,-1.26],P<0.00001),total cholesterol(MD=-0.96,95%CI[-1.19,-0.73],P<0.00001),triglycerides(MD=-0.52,95%CI[-0.65,-0.40],P<0.00001),and adverse reactions(OR=0.64,95%CI[0.43,0.97],P=0.03)of the observation group were better than the control group.Conclusion The combination of compound Danshen Dripping Pills with isosorbide mononitrate and conventional Western medicine has significant clinical efficacy and high safety in the treatment of coronary heart disease and angina pectoris.However,more well-designed,multi-sample,multi-center,and double-blind RCT are needed to provide evidence support.
作者 张丽萍 程青霞 郭蕾 路凡 孟诗琪 袁工植 ZHANG Liping;CHENG Qingxia;GUO Lei;LU Fan;MENG Shiqi;YUAN Gongzhi(Guizhou University of Traditional Chinese Medicine,Department of Geriatrics,the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guizhou,Guiyang 550005,China)
出处 《中国医药科学》 2024年第8期86-90,共5页 China Medicine And Pharmacy
关键词 复方丹参滴丸 单硝酸异山梨酯 冠心病 心绞痛 META分析 Compound Danshen Dripping Pills Isosorbide mononitrate Coronary heart disease Angina pectoris Meta-analysis
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