摘要
目的:探讨二甲双胍联合阿卡波糖治疗2型糖尿病的临床效果。方法:选取2022年1月—2023年3月山东菏泽定陶区人民医院收治的68例2型糖尿病患者作为研究对象,采用随机数字表法分成观察组和对照组,各34例。对照组应用阿卡波糖治疗,观察组在对照组基础上采用二甲双胍治疗。比较两组血糖水平、胰岛功能、临床疗效及不良反应发生情况。结果:治疗前,两组糖化血红蛋白(HbA_(1c))、空腹血糖(FPG)、餐后2 h血糖(2 hPBG)水平比较,差异无统计学意义(P>0.05);治疗后,两组HbA_(1c)、FPG、2 hPBG水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组胰岛β细胞功能指数、胰岛素抵抗指数比较,差异无统计学意义(P>0.05);治疗后,两组胰岛β细胞功能指数高于治疗前,且观察组高于对照组;两组胰岛素抵抗指数低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.016)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:二甲双胍联合阿卡波糖治疗2型糖尿病的临床效果较好,能够降低患者血糖水平,提高胰岛功能,且安全性较高。
Objective:To explore the clinical effect of metformin combined with acarbose in the treatment of type 2 diabetes mellitus.Methods:A total of 68 patients with type 2 diabetes mellitus admitted to Heze City Dingtao District People's Hospital in Shandong Province from January 2022 to March 2023 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 34 cases in each group.The control group was treated with acarbose,while the observation group was treated with metformin on the basis of the control group.The blood glucose levels,pancreatic islet function,clinical efficacy and adverse reactions of the two groups were compared between two groups.Results:Before treatment,there was no significant difference in the levels of glycosylated hemoglobin(HbA_(1c)),fasting blood glucose(FPG)and 2 h postprandial blood glucose(2 hPBG)between the two groups(P>0.05);After treatment,the levels of HbA_(1c),FPG and 2 hPBG in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,with a statistically significant difference(P<0.05).Before treatment,there was no significant difference in the pancreatic isletβ-cell function index and insulin resistance index between the two groups(P>0.05);After treatment,the pancreatic isletβ-cell function index in the two groups was higher than that before treatment,and this index in the observation group was higher than that in the control group;the insulin resistance index in the two groups was lower than that before treatment,and this index in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.016).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Metformin combined with acarbose has good clinical effect in the treatment of type 2 diabetes mellitus,and can reduce the blood glucose levels,improve and pancreatic islet function,and have high safety.
作者
史海涛
Shi Haitao(Heze City Dingtao District People's Hospital,Heze 274100,Shandong Province,China)
出处
《中国社区医师》
2024年第7期20-22,共3页
Chinese Community Doctors
关键词
二甲双胍缓释片
2型糖尿病
胰岛功能
Metformin sustained-release tablets
Type 2 diabetes mellitus
Pancreatic islet function
