摘要
目的:分析血清淀粉样蛋白(SAA)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)检测在急性胰腺炎诊断中的应用价值。方法:选取2021年7月—2023年1月北京四季青医院收治的76例急性胰腺炎患者作为观察组,根据病情严重程度将观察组分为重症组与轻症组,根据预后情况将观察组分为预后不良组与预后良好组,选取同期76例健康体检者作为对照组。所有研究对象均进行SAA、CRP、PCT及IL-6检测。比较观察组与对照组、重症组与轻症组、预后良好组与预后不良组SAA、CRP、PCT及IL-6水平,分析各指标预测急性胰腺炎预后不良的效能。结果:观察组SAA、CRP、PCT与IL-6水平高于对照组,重症组SAA、CRP、PCT与IL-6水平高于轻症组,预后不良组SAA、CRP、PCT与IL-6水平高于预后良好组,差异有统计学意义(P<0.001)。血清SAA、CRP、PCT与IL-6预测急性胰腺炎患者预后不良的试者工作特征曲线下总面积分别为0.880、0.838、0.889、0.847,均具有良好的预测价值。结论:SAA、CRP、PCT及IL-6检测在急性胰腺炎诊断中的应用价值较高,能够反映患者病情严重程度,预测预后情况。
Objective:To analyze the application value of serum amyloid protein(SAA),C-reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)detection for the diagnosis of acute pancreatitis.Methods:A total of 76 patients with acute pancreatitis admitted to Beijing Sijiqing Hospital from July 2021 to January 2023 were selected as the observation group.According to the severity of the disease,the observation group was divided into severe group and mild group.According to the prognosis,the observation group was divided into poor prognosis group and good prognosis group.Another 76 health examination subjects during the same period were selected as the control group.All subjects were tested for SAA,CRP,PCT,and IL-6.The levels of SAA,CRP,PCT and IL-6 between the observation group and the control group,between the severe group and the mild group,between the good prognosis group and the poor prognosis group were compared.The diagnostic efficiency of each index in predicting the poor prognosis of acute pancreatitis was analyzed.Results:The levels of SAA,CRP,PCT and IL-6 in the observation group were higher than those in the control group,the levels of SAA,CRP,PCT and IL-6 in the severe group were higher than those in the mild group,the levels of SAA,CRP,PCT and IL-6 in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P<0.001).The total area under the receiver operating characteristic curve of serum SAA,CRP,PCT and IL-6 in predicting the poor prognosis of patients with acute pancreatitis was 0.880,0.838,0.889 and 0.847,respectively,indicating good predictive value.Conclusion:The detection of SAA,CRP,PCT and IL-6 in the diagnosis of acute pancreatitis has high application value,and can reflect the severity of the patient's disease condition and predict the prognosis.
作者
何金玉
He Jinyu(Department of Clinical Laboratory,Beijing Sijiqing Hospital,Beijing 100097,China)
出处
《中国社区医师》
2024年第7期83-85,共3页
Chinese Community Doctors
