摘要
为探究胡椒属植物小叶爬崖香(Piper sintenense Hatusima)中苷类化学成分,采用硅胶、ODS、MCI GEL CHP20P、Sephadex LH-20柱色谱和半制备高效液相等色谱技术,从小叶爬崖香95%乙醇提取物的正丁醇部位分离获得9个苷类化合物。根据理化性质及核磁共振数据,以上化合物被鉴定为(2S)-2-羟基-1-(4-羟基-3-甲氧基苯基)-1-丙酮-2-O-β-D-葡萄糖苷(1)、苯乙醇-β-D-葡萄糖苷(2)、苄醇-β-巢菜糖苷(3)、苄醇-β-樱草糖苷(4)、苯乙醇-β-D-呋喃芹菜糖基-(1''→2')-β-D-葡萄糖苷(5)、红景天苷(6)、苯乙醇-β-樱草糖苷(7)、(顺)-3-己烯醇-β-巢菜糖苷(8)、(顺)-3-己烯醇-β-樱草糖苷(9)。其中化合物1为新化合物,化合物3~9为首次从胡椒属中分离得到。
In order to investigate the chemical constituents of glycosides in Piper sintenense Hatusima,column chromatographic techniques such as silica gel,ODS,MCI GEL CHP20P,Sephadex LH-20,and semi-preparative high performance liquid chromatography were used to afford nine glycosides from the n-butanol part of the 95%ethanol extract of Piper sintenense Hatusima.Based on the physicochemical properties and NMR data,the above compounds were identified as(2S)-2-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone-2-O-β-Dglucopyranoside(1),2-phenylethylβ-D-glucopyranoside(2),benzylα-L-arabinopyranosyl-(1''→6')-β-Dglucopyranoside(3),benzylβ-D-xylopyanosyl-(1''→6')-β-D-glucopyranoside(4),phenethylβ-D-apiofuranosyl-(1''→2')-β-D-glucopyranoside(5),salidroside(6),phenethanolβ-D-xylopyanosyl-(1''→6')-β-D-glucopyranoside(7),(Z)-hexenyl-O-α-L-arabinopyranosyl-(1''→6')-O-β-D-glucopyranoside(8),(Z)-hexenyl-O-β-D-xylopyanosyl-(1''→6')-O-β-D-glucopyranoside(9).Compound 1 was identified as a new compound,and compounds 3-9 were isolated from the genus Piper for the first time.
作者
涂鹏煌
姚志仁
金美玲
宁冠宇
黄亚萍
潘珂
殷志琦
TU Penghuang;YAO Zhiren;JIN Meiling;NING Guanyu;HUANG Yaping;PAN Ke;YIN Zhiqi(Department of TCMs Pharmaceuticals,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198;Department of Natural Medicinal Chemistry,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2024年第2期202-208,共7页
Journal of China Pharmaceutical University
关键词
胡椒属
小叶爬崖香
化学成分
糖苷
分离鉴定
Piper spp.
Piper sintenense Hatusima
chemical constituents
glycoside
isolation and identification
