摘要
目的探讨紫癜性肾炎(henoch-sch9nlein purpura nephritis,HSPN)患儿合并肺炎支原体(mycoplasma pneumoniae,MP)急性感染实验室预测指标。方法回顾性分析2017年3月~2022年6月兰州大学第二医院收治的0~16岁135例HSPN患儿。根据是否合并MP急性感染分为HSPN合并MP急性感染组(HSPN-MP组,n=50)和HSPN未合并MP急性感染组(HSPN组,n=85),分析两组患儿的实验室指标,并对差异有统计学意义的指标进行多因素Logistic回归分析,采用受试者工作特征(receiver operating characteristic,ROC)曲线评价独立危险因素对HSPN合并MP急性感染的预测价值。结果HSPN-MP组患儿外周血免疫球蛋白M(immunoglobulin M,IgM)、血小板分布宽度(platelet distribution width,PDW)水平均显著高于HSPN组,而白细胞计数(white blood cell,WBC)、红细胞体积分布宽度变异系数(coefficient variation of red blood cell volume distribution,RDW-CV)、淋巴细胞计数(lymphocyte,LY)水平均显著低于HSPN组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,PDW、IgM分别是HSPN合并MP急性感染的独立危险因素(P<0.05)。PDW、IgM及两者联合诊断HSPN合并MP急性感染的曲线下面积(area under the curve,AUC)分别为0.628、0.690和0.716;敏感度分别为80.0%、48.0%和60.0%;特异性分别为41.2%、85.0%和84.7%。结论外周血PDW、IgM升高分别是HSPN合并MP急性感染的独立危险因素,PDW联合IgM检测可以预测HSPN患儿合并MP急性感染。
Objective To investigate the laboratory predictive indicators of acute infection with mycoplasma pneumoniae(MP)in children with henoch-sch nlein purpura nephritis(HSPN).Methods A retrospective analysis was performed on 135 children aged 0-16 years with HSPN admitted to the Lanzhou University Second Hospital from March 2017 to June 2022.According to whether they were combined with acute infection of MP,they were divided into HSPN combined with MP acute infection group(HSPN-MP group,n=50)and non-MP acute infection group(HSPN group,n=85),and the laboratory indicators of the children in the two groups were analyzed,and multivariate Logistic regression analysis was performed for the indicators with statistically differences,and the receiver operating characteristic(ROC)curve was used to evaluate the predictive value of independent risk factors for HSPN combined with MP acute infection.Results The levels of immunoglobulin M(IgM)and platelet distribution width(PDW)in peripheral blood of children in the HSPN-MP group were significantly higher than those in the HSPN group,while the white blood cell(WBC)and coefficient variation of red blood cell volume distribution(RDW-CV)and lymphocyte(LY)were significantly lower than those in the HSPN group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that PDW and IgM were independent risk factors for HSPN combined with MP acute infection(P<0.05).The area under the curve(AUC)of PDW,IgM and the combined diagnosis of HSPN combined with MP acute infection were 0.628,0.690 and 0.716,and the sensitivity were 80.0%,48.0%and 60.0%,respectively,the specificity were 41.2%,85.0%and 84.7%,respectively.Conclusion The increase of PDW and IgM in peripheral blood is an independent risk factor for HSPN combined with MP acute infection,and PDW combined with IgM testing can predict MP acute infection in children with HSPN.
作者
曹永丽
赵家敏
祝静
丁霞
黄莉
倪倩
CAO Yongli;ZHAO Jiamin;ZHU Jing(Department of Pediatric Respiratory Medicine,Lanzhou University Second Hospital,Gansu 730000,China)
出处
《医学研究杂志》
2024年第3期115-119,共5页
Journal of Medical Research
基金
甘肃省自然科学基金资助项目(22JR5RA1006)
甘肃省兰州市科技发展指导性计划项目(2020-ZD-98)
兰州大学第二医院“萃英科技创新”计划项目(CY-2020-MS13)。
关键词
肺炎支原体
紫癜性肾炎
预测指标
儿童
Mycoplasma pneumoniae
Purpuric nephritis
Predictors
Children
