摘要
目的 探究血清黄体生成素(LH)基础值联合神经肽吻素(Kisspeptin)水平诊断女童中枢性性早熟(CPP)的临床价值。方法 回顾性选取2020年1月至2023年3月浙江省舟山市妇女儿童医院收治的115例CPP女童纳入研究组,同时选取进行健康体检的女童120名纳入对照组。比较两组LH基础值和Kisspeptin水平及临床相关资料;分析女童CPP发生的影响因素;受试者操作特征曲线评估血清LH基础值联合Kisspeptin水平对女童CPP发生的诊断价值。结果 研究组LH基础值、Kisspeptin水平高于对照组(P<0.05)。研究组骨龄、雌二醇、血清卵泡刺激素基础值、催乳素、卵巢体积、子宫体积高于对照组(P<0.05)。LH基础值(OR=1.857)、Kisspeptin水平(OR=2.353)是女童CPP发生的独立危险因素(P<0.05)。血清LH基础值、Kisspeptin及二者联合预测女童CPP发生的曲线下面积分别为0.759、0.730、0.930。结论 LH基础值与Kisspeptin水平在CPP女童血清中异常高表达,是影响女童CPP发生的独立危险因素,LH基础值与Kisspeptin水平联合检测可较好地预测女童CPP的发生。
Objective To explore the clinical value of serum basal value of luteinizing hormone(LH)combined with Kisspeptin level in the diagnosis of central precocious puberty(CPP)in girls.Methods A total of 115 CPP in girls admitted to Zhoushan Women and Children’s Hospital of Zhejiang Province from January 2020 to March 2023 were selected as study group,while 120 girls who underwent health examinations during the same period were selected as control group.The basal value of LH,Kisspeptin level,and clinical data were compared between two groups;the influencing factors of CPP in girls were analyzed;and the diagnostic value of serum basal value of LH combined with Kisspeptin level for CPP in girls was evaluated by receiver operating characteristic curve.Results The basal value of LH and Kisspeptin level of study group were higher than those of control group(P<0.05).The bone age,estradiol,basal serum follicle-stimulating hormone,prolactin,ovarian volume,and uterine volume of study group were higher than those of control group(P<0.05).The basal value of LH(OR=1.857)and Kisspeptin level(OR=2.353)were independent risk factors for the occurrence of CPP in girls(P<0.05).The area under the curve of basal value of LH,Kisspeptin,and their combination for diagnosing CPP in girls were 0.759,0.730,and 0.930,respectively.Conclusion The abnormal high expression of basal value of LH and Kisspeptin level in the serum of CPP in girls,and they are independent risk factors affecting the occurrence of CPP in girls.The combined detection of the basal value of LH level and Kisspeptin level can better diagnose the development of CPP in girls.
作者
宋航
潘辉
杨晓岚
SONG Hang;PAN Hui;YANG Xiaolan(Department of Clinical Laboratory,Zhoushan Women and Children’s Hospital,Zhejiang Province,Zhoushan316000,China)
出处
《中国医药导报》
CAS
2024年第9期104-107,共4页
China Medical Herald
基金
浙江省医药卫生科技计划项目(2020KY369)。
关键词
黄体生成素基础值
神经肽吻素
女童中枢性性早熟
诊断价值
Basal value of luteinizing hormone
Kisspeptin
Central precocious puberty in girls
Diagnostic value
