摘要
目前针对流感的防控虽然有疫苗、药物等多种措施,但其效果并不显著。全球每年还有数以万计因流感病毒患病或死亡的病例,其中乙型流感的占比也在逐年增加。与甲型流感病毒(Influenza A virus,IAV)相比,机体固有免疫抵御乙型流感病毒(Influenza B virus,IBV)的相关研究相对较少,而深入系统地了解IBV生命周期各个环节与固有免疫之间的博弈对临床治疗IBV感染具有指导意义。固有免疫系统作为抵抗病毒侵染的重要防线,能够通过一系列复杂而有序的级联信号传导,针对IBV复制的各个环节进行精准打击。这其中就包括固有免疫反应针对IBV对靶细胞吸附、入胞、病毒核糖核蛋白入/出核、转录复制以及病毒组装出芽等环节的抑制。本文旨在综述固有免疫在IBV生命周期不同阶段所发挥的作用,有助于系统了解机体针对IBV的抗病毒免疫反应的特点,为寻找新的抗病毒靶点和新的抗病毒策略提供理论基础。
Currently,there are various methods involved with vaccine and therapy for influenza infections.However,the related measures play the weak roles in preventing influenza epidemics in the world.The number of patients infected with influenza virus remains high each year,and the proportion of influenza B is also increasing year by year.However,as immune responses toward IBV are largely understudied compared to that of IAV,it is necessary to deeply investigate the roles of innate immune response in the life cycle of IBV for better understanding the interaction between innate immune responses and the steps of IBV life cycle and providing some valuable references in clinictherapy.Serving as an important defense line against viral infection,innate immune system can stimulate a series of cellular signals to precisely aim to every step of IBV infection,including viral binding,entry,ribonucleoprotein input/output for nucleus and viral assembly.Systemic researches on innate immune system mediated signal pathways will benefit for understanding the characterizations of antiviral responses to IBV infection and providing some ideal targets for antiviral strategy.
作者
杨宣叶
高明阳
王进千
胡欣妍
吴玉湖
马忠仁
马晓霞
YANG Xuanye;GAO Mingyang;WANG Jinqian;HU Xinyan;WU Yuhu;MA Zhongren;MA Xiaoxia(Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission,Biomedical Research Center,Northwest Minzu University,Lanzhou 730030,China;Gansu Tech Innovation Center of Animal Cell,Biomedical Research Center,Northwest Minzu University;College of Life Science and Engineering,Northwest Minzu University)
出处
《中国病原生物学杂志》
CSCD
北大核心
2024年第5期614-618,共5页
Journal of Pathogen Biology
基金
中央高校基本科研业务费专项资金资助(No.31920220134)
甘肃省自然科学基金(No.20JR5RA505)。
