摘要
目的探讨阿胶珠联合地屈孕酮治疗妊娠早期先兆流产的临床效果。方法选取2021年3月至2022年3月江西省妇幼保健院收治的60例妊娠早期先兆流产患者,采取随机数字表法进行分组,两组各30例。两组患者入院后即采取常规对症治疗,对照组在此基础上接受地屈孕酮治疗,观察组在对照组基础上加用阿胶珠治疗。比较两组患者的临床疗效,症状缓解时间,治疗前后血清激素指标[(HCG)、雌二醇(E2)、孕酮(P)]检测结果以及妊娠结局(流产、早产、足月产)的差异。结果观察组疗程结束后治疗总有效率为93.33%,高于对照组的73.33%,数据间对比差异有统计学意义(P<0.05);观察组阴道出血停止时间、腰腹部疼痛缓解时间、腰膝酸软缓解时间均短于对照组,数据间对比差异有统计学意义(P<0.05);观察组治疗后血清HCG、E2、P检测结果均高于对照组,数据间对比差异有统计学意义(P<0.05);观察组足月产率为93.33%,高于对照组的73.33%,数据间对比差异有统计学意义(P<0.05)。结论对于妊娠早期先兆流产患者,采取阿胶珠联合地屈孕酮治疗,其疗效显著,可以改善患者的症状、血清激素指标和妊娠结局,值得临床推荐。
Objective To investigate the clinical effect of ejiaozhu combined with dydrogesterone in the treatment of threatened abortion in early pregnancy.Methods 60 patients with threatened abortion in early pregnancy were studied from March 2021 to March 2022 in Jiangxi Maternal and Child Health Hospital.Randomized number table method was used for grouping,30 cases in each group.The two groups of patients were treated with routine symptomatic treatment after admission.The control group was treated with dydrogesterone on this basis.The observation group was treated with ejiaozhu on the basis of the control group.The clinical efficacy,symptom relief time,serum hormone index[(HCG),estradiol(E2),progesterone(P)]test results and pregnancy outcome(abortion,premature delivery,term delivery)were compared between the two groups.Results After the treatment,the total effective rate of treatment in the observation group was 93.33%,higher than 73.33%in the control group,with significant difference between the data(P<0.05);the stopping time of vaginal bleeding,the relieving time of waist and abdominal pain,and the relieving time of waist and knee tenderness in the observation group were shorter than those in the control group,with significant difference between the data(P<0.05);the detection results of serum HCG,E2 and P in the observation group were higher than those in the control group after treatment,and the difference between the data was significant(P<0.05);the full-term rate in the observation group was 93.33%,which was higher than 73.33%in the control group.There was a significant difference between the data(P<0.05).Conclusion For the patients with threatened abortion in early pregnancy,the treatment of ejiaozhu combined with dydrogesterone has a significant effect,which can improve the symptoms,serum hormone indicators and pregnancy outcome of the patients,and is worthy of clinical recommendation.
作者
谢小花
XIE Xiaohua(Jiangxi Maternal and Child Health Hospital,Nanchang Jiangxi 330038,China.)
出处
《药品评价》
CAS
2024年第1期127-130,共4页
Drug Evaluation
关键词
妊娠早期先兆流产
阿胶珠
地屈孕酮
激素
妊娠结局
Threatened abortion in early pregnancy
Ejiaozhu
Dydrogesterone
Hormones
Pregnancy outcome
