摘要
作为一种重要的化工原料和氘代中间体,氘代甲醇(CD_(3)OD)被广泛应用于核磁共振试剂、氘代药物中间体、光电材料改性,但其在CO-CO_(2)体系中的催化合成效率仍有待提高。文章通过热力学计算CO-CO_(2)加D_(2)制备氘代甲醇反应条件对反应物平衡转化率的影响,并采用CuO/ZnO/Al_(2)O_(3)催化剂,设计正交实验探索合成氘代甲醇的最佳反应条件。以氘代甲醇时空产率为指标,实验获得的最优反应条件为:反应温度240℃,反应压强5 MPa;n(D_(2))/n(CO+CO_(2))为3,n(CO)/n(CO_(2))为1。
As an important chemical raw material and deuterated intermediate,deuterated methanol(CD_(3)OD)has been widely used in nuclear magnetic resonance reagents,deuterated drug intermediates and photoelectric materials modification,but its catalytic synthesis efficiency in CO-CO_(2)system still needs to be improved.Herein,the effect of reaction conditions on the equilibrium conversion rate during the process of preparation of deuterated methanol from CO-CO_(2)and D_(2)is calculatedally.In the case of CuO/ZnO/Al_(2)O_(3)catalyst,the optimal reaction conditions for the synthesis of deuterated methanol is investigated by orthogonal experiment.Taking the space-time yield of deuterated methanol as the index,the optimal reaction conditions obtained in the experiment are as follows:the reaction temperature is 240℃,the reaction pressure is 5 MPa;the molar ratio of D_(2)/(CO+CO_(2))is 3,and the molar ratio of CO/CO_(2)is 1.
作者
龙涛
周锋
张伟
吴泓
王建
陈霖
Long Tao;Zhou Feng;Zhang Wei;Wu Hong;Wang Jian;Chen Lin(Hunan Keimeite Gases Co.,Ltd.,Yueyang 414020,China;School of Metallurgy and Environment,Central South University,Changsha 410083,China)
出处
《云南化工》
CAS
2024年第4期44-53,共10页
Yunnan Chemical Technology
基金
国家重点基础研究发展计划(2018YFC1901604)
湖南省自然科学基金(2023JJ30667)
中南大学研究生教育教学改革项目(2021JGB117)。
关键词
氘代甲醇
热力学
合成条件优化
Deuterated Methanol
Thermodynamic
Optimization of Synthetic Conditions
