摘要
越来越多证据表明代谢综合征、心血管疾病和慢性肾脏病具有相同的病理生理机制,存在相互有害的促进作用,2023年10月美国心脏协会提出“心血管-肾脏-代谢综合征(cardiovascular-kidney-metabolic syndrome,CKM)”主席倡议,确定了CKM综合征定义、分期,提出相关风险筛查、预测和管理建议。CKM综合征的提出有助有更加全面、系统认识代谢性异常或疾病、心血管疾病和肾脏疾病三者相互关系,不同分期有助于理解代谢异常或代谢性疾病如何逐步引起心血管和肾脏疾病,以及心肾疾病相互促进并反馈加重代谢异常,相关风险筛查、预测和管理建议为其早期预防、诊断、干预提供方案。随着对CKM综合征认识的提高和研究的深入,人类有望逐步克服因为不良生活方式引起的代谢异常或代谢性疾病及其导致的心血管疾病、肾脏疾病。
More and more evidence suggest that metabolic syndrome,cardiovascular disease,and chronic kidney disease share the similar physiological and pathological mechanism,with mutual promotion of their unfavorable effects.In Oct.2023,the American Heart Association(AHA)published a chairman's advisory on cardiovascular-kidney-metabolic syndrome(CKM),in which the definition and stage of CKM syndrome were delineated,and the prediction,screening and management of relevant risks in CKM syndrome were recommended.The proposal of CKM syndrome contributes to the comprehensive and systematic understanding of the relationship among metabolic syndrome,cardiovascular diseases and kidney diseases.The stage of CKM syndrome is helpful for our comprehension on the processes of metabolic abnormalities developing to cardiovascular and kidney diseases,the mutual promotion of cardiovascular and kidney diseases,and the negative feedback effects of cardiovascular and kidney diseases on metabolic abnormalities.The stage of CKM syndrome is also useful for prediction,screening and management of relevant risks in CKM syndrome,and for making guidelines for early prevention,diagnosis and intervention of CKM syndrome.With the progresses in research and our understanding on CKM syndrome,metabolism abnormalities and metabolic diseases caused by unhealthy lifestyle and the resultant cardiovascular and kidney diseases are expected to be diminished.
作者
王方豫
高月明
邓振领
王悦
WANG Fang-yu;GAO Yue-ming;DENG Zhen-ling;WANG Yue(Department of Nephrology,Peking University Third Hospital,Beijing 100191,China)
出处
《中国血液净化》
CSCD
2024年第5期368-371,共4页
Chinese Journal of Blood Purification
关键词
代谢综合征
心血管疾病
慢性肾脏病
心血管-肾脏-代谢综合征
Metabolic syndrome
Cardiovascular disease
Chronic kidney disease
Cardiovascular-kidney-metabolic syndrome
