摘要
目的:探讨瑞马唑仑复合丙泊酚在全身麻醉手术中的安全性与有效性。方法:选取2022年1月—2023年6月于江苏大学附属张家港澳洋医院拟行腹腔镜胆囊切除术的患者80例作为研究对象,以随机数字表法分为对照组(采取丙泊酚常规麻醉诱导与维持)和观察组(采取瑞马唑仑复合丙泊酚麻醉诱导与维持),各40例。比较两组麻醉恢复指标、生命体征变化情况、认知功能、不良反应发生率。结果:观察组睁眼时间、拔管时间、麻醉恢复室停留时间均短于对照组,差异有统计学意义(P<0.001);插入喉罩即刻、插入喉罩后1 min、插入喉罩后5 min,两组平均动脉压、心率水平低于诱导前,观察组高于对照组,差异有统计学意义(P<0.05);术后1、6 h,观察组简易智能精神状态检查量表评分高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P=0.001)。结论:瑞马唑仑复合丙泊酚在全身麻醉手术中应用可促使患者更快清醒,利于患者认知功能恢复,稳定生命体征,安全性高。
Objective:To investigate the safety and efficacy of remimazolam compounded with propofol in general anesthesia surgery.Methods:Eighty patients who were to undergo laparoscopic cholecystectomy at Zhangjiagang Aoyang Hospital Affiliated to Jiangsu University from January 2022 to June 2023 were selected as the study subjects,and were divided into the control group(adopting propofol conventional anesthesia induction and maintenance)and the observation group(adopting remimazolam compounded with propofol anesthesia induction and maintenance)by the method of randomized numerical table,with forty cases in each group.Compare the anesthesia recovery indexes,vital signs changes,cognitive function,and the incidence of adverse reactions in the two groups.Results:The observation group's eye opening time,extubation time,and stay time in the anesthesia recovery room were shorter than that of the control group,and the difference was statistically significant(P<0.001);at the immediate moment of insertion of the laryngeal mask,1 min after the insertion of the laryngeal mask,and 5 min after the insertion of the laryngeal mask,the levels of mean arterial pressure and heart rate of the two groups were lower than those before induction,and those of the observation group were higher than those of the control group,and the difference was statistically significant(P<0.05);at 1 and 6 h postoperatively,the score of Simple Intelligent Mental State Examination Scale of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);the incidence rate of adverse reactions of the observation group was lower than that of the control group,and the difference was statistically significant(P=0.001).Conclusion:The application of remimazolam compounded with propofol in general anesthesia surgery can prompt patients to wake up faster,facilitate the recovery of cognitive function,stabilize vital signs,and is safe.
作者
许镇
Xu Zhen(Department of Anesthesiology,Zhangjiagang Aoyang Hospital Affiliated to Jiangsu University,Zhangjiagang 215600,Jiangsu Province,China)
出处
《中外医药研究》
2024年第7期45-47,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
瑞马唑仑
丙泊酚
全身麻醉
手术
安全性
有效性
Remimazolam
Propofol
General anesthesia
Surgery
Safety
Effectiveness
