摘要
真菌毒素是病原真菌产生的次级代谢产物,常污染多种农作物,通过食物链对人畜健康造成严重危害。真菌毒素具有多种毒性作用,包括神经毒性、肝毒性、免疫毒性、致畸性和致癌性等,但其免疫毒性机制尚不完全清楚。树突状细胞(DCs)作为功能最强大的抗原提呈细胞,在启动先天免疫和获得性免疫应答中发挥重要作用。现有研究发现真菌毒素能够影响DCs的内吞作用、刺激T细胞活化的能力以及细胞因子和趋化因子的分泌,本文旨在综述真菌毒素对DCs免疫应答的影响,为后续研究阐明真菌毒素的免疫毒性机制提供参考。
Mycotoxins are secondary metabolites produced by pathogenic fungi.They often contaminate various crops,and are detrimental to human and animal health.Mycotoxins have a variety of toxic effects,such as neurotoxicity,hepatotoxicity,immunotoxicity,teratogenicity,and carcinogenicity.However,the mechanism of immunotoxicity is still unclear.Dendritic cells(DCs),as the most potent antigen presenting cells,play a vital role in initiating innate and adaptive immune responses.Previous studies have found that mycotoxins can affect the endocytosis of DCs,the ability to stimulate T cell activation,the secretion of cytokines and chemokines.Thus,this review is aim to summarize the effects of mycotoxins on DCs-mediated immune responses,which may provide reference for researches to clarify the immunotoxicity mechanism of mycotoxins.
作者
于欢
尚国富
欧沙
洪亮
曾柱
胡祖权
YU Huan;SHANG Guofu;OU Sha;HONG Liang;ZENG Zhu;HU Zuquan(School of Biology and Engineering,Key Laboratory of Infectious Immune and Antibody Engineering in Guizhou Province,State Key Laboratory of Func-tions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang 550025,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2024年第4期862-865,871,共5页
Chinese Journal of Immunology
基金
国家自然科学基金项目(21906036)
贵州省科技计划项目(黔科合基础-ZK[2021]重点029,黔科合支撑[2019]2787号,黔科合平台人才[2016]5676)。
