摘要
伪基因一直以来被认为是无功能的基因组化石,是人类进化的证据。然而,近年发现伪基因在生理和病理过程均发挥重要作用,尤其是在肿瘤中,以亲代基因依赖和亲代基因不依赖方式调节肿瘤发生发展,包括肝癌。本文主要总结伪基因及其在肝癌细胞增殖、凋亡、侵袭和转移中的研究进展,为突破肝癌治疗瓶颈提供新思路。
Pseudogenes have long been regarded as fossilized,nonfunctional genomes that are evidence of human evolution.However,in recent years,pseudogenes have been found to play an important role in both physiological and pathological processes,especially in tumors,regulating occurrence and development of tumors in parental gene dependence and parental gene independence,including liver cancer.In this paper,we summarized research progress of pseudogenes and their roles in proliferation,apoptosis,invasion and metastasis of liver cancer cells,providing new ideas for treatment of liver cancer.
作者
郭文杰
刘芳
高娜
陈彻
楚惠媛
GUO Wenjie;LIU Fang;GAO Na;CHEN Che;CHU Huiyuan(Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2024年第4期894-896,F0003,F0004,共5页
Chinese Journal of Immunology
基金
甘肃省自然科学基金项目(20JR10RA311)
兰州市城关区科技计划项目(2020JSCX0084)
甘肃省高等学校科研项目(2017A-051)。
关键词
伪基因
肝癌
增殖
侵袭
转移
Pseudogene
Liver cancer
Proliferation
Invasion
Metastasis
