摘要
目的探讨硫辛酸和左旋多巴联合恩他卡朋及悬吊康复治疗帕金森病(Parkinson’s disease,PD)的疗效。方法选取收治的160例帕金森病患者为研究对象。按照随机数字表法分为对照组和观察组,各80例。对照组给予左旋多巴和恩他卡朋治疗,观察组在对照组治疗的基础上加用硫辛酸与悬吊康复治疗。治疗2个月后,比较2组的临床疗效、血清炎症因子-α[肿瘤坏死因子-ɑ(tumor necrosis factor,TNF-ɑ)、白细胞介素-6(interleukin-6,IL-6)、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)]以及自主神经功能[PD自主神经症状(the scale for outcomes in PD for autonomic symptoms,SCOPA-AUT)量表]、睡眠质量[匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)量表]和日常生活活动能力[PD统一评分(unified parkinsons disease rating scale,UPDRS)量表第Ⅱ部分]的变化。结果观察组的总有效率(88.75%)明显高于对照组(76.25%),P<0.05。治疗后,2组TNF-ɑ、IL-6及hs-CRP水平均降低(P<0.05),且观察组更低(P<0.05)。2组各量表评分均降低(P<0.05),且观察组更低(P<0.05)。结论硫辛酸和左旋多巴联合恩他卡朋及悬吊康复治疗PD能显著降低血清炎症因子水平,改善患者自主神经功能,提升患者睡眠质量和日常生活活动能力。
Objective To investigate the efficacy of lipoic acid and levodopa combined with entacapone and suspension rehabilitation in the treatment of Parkinson’s disease(PD).Methods 160 patients with PD were enrolled and divided into control group and observation group according to the random number table method,with 80 cases in each group.The control group was treated with levodopa and entacapone,and the observation group was treated with lipoic acid and suspension rehabilitation on the basis of the control group.After 2 months of treatment,the clinical efficacy,serum inflammatory factors[tumor necrosis factor-α(TNF-ɑ),interleukin-6(IL-6),high-sensitivity C-reactive protein(hs-CRP)],autonomic nerve function[PD autonomic symptoms(SCOPA-AUT)scale],sleep quality[Pittsburgh sleep quality index(PSQI)scale]and activities of daily living[unified PD rating scale(UPDRS)partⅡ]were compared between the 2 groups.Results The total effective rate of the observation group was 88.75%,which was significantly higher than 76.25%of the control group(P<0.05).After treatment,the levels of TNF-ɑ,IL-6 and hs-CRP in the 2 groups decreased(P<0.05),and those in the observation group were lower than that in the control group(P<0.05).The total score of SCOPA-AUT scale and each subscale score,PSQI scale score and UPDRS partⅡscore of the 2 groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).Conclusion Lipoic acid and levodopa combined with entacapone and suspension rehabilitation in the treatment of PD can significantly reduce the level of serum inflammatory factors,improve the autonomic nerve function of patients,improve the sleep quality and activities of daily living of patients,with good clinical efficacy.
作者
吴李娜
卢年华
许贵
WU Li’na;LU Nianhua;XU Gui(Department of Rehabilitation Medicine,Qianhai Life Insurance Nanning Hospital,Nanning 530200,China;Department of Laboratory,Qianhai Life Insurance Nanning Hospital,Nanning 530200,China)
出处
《西北药学杂志》
CAS
2024年第3期184-188,共5页
Northwest Pharmaceutical Journal
基金
青年基金项目(编号:2020JJ5803)。
关键词
硫辛酸
恩他卡朋
悬吊康复
帕金森病(PD)
临床疗效
自主神经功能
lipoic acid
entacapone
suspension rehabilitation
Parkinson’s disease
clinical efficacy
autonomic nerve function
