摘要
白介素10(IL-10)是能够参与机体免疫的一种多功能细胞因子,由单核细胞、巨噬细胞等多种免疫细胞分泌,在肿瘤、感染、免疫缺陷等多种疾病的发生发展过程中发挥着重要的调节作用。多种硬骨鱼IL-10基因被克隆表达,被证实具有免疫调节作用,目前已有不少关于鱼类IL-10的生物活性、作用机制、调节机制的研究。本文根据已有报道,从鱼类IL-10的基因结构、转录表达、来源与进化、生物学活性及功能、鱼类IL-10受体及信号通路等5个方面进行了综述,为鱼类IL-10的研究与应用提供依据。
Interleukin 10(IL-10)is a multifunctional cytokine that participates in the immunity of the body.It is secreted by various immune cells such as monocytes and macrophages,and plays an important role in the development of various diseases such as tumor,infection and immune diseases.A variety of scleractinian fish IL-10 has been clonally expressed and has shown immunomodulatory effects,and there are a number of studies on the biological activity,mechanism of action,and regulatory mechanism of IL-10 in fish.To provide a reference for future studies and applications of fish IL-10,a literature review is conducted in terms of its genetic structure,transcriptional expression,origin and evolution,biological activities and functions,as well as fish IL-10 receptor and signaling pathway.
作者
黎秋男
李书含
周永恒
耿毅
黄小丽
陈德芳
欧阳萍
LI Qiunan;LI Shuhan;ZHOU Yongheng;GENG Yi;HUANG Xiaoli;CHEN Defang;OUYANG Ping(College of Veterinary Medicine,Sichuan Agricultural University,Chengdu 611130,China;College of Animal Science and Technology,Sichuan Agricultural University,Chengdu 611130,China)
出处
《水产学报》
CAS
CSCD
北大核心
2024年第4期22-32,共11页
Journal of Fisheries of China
基金
国家自然科学基金(32102844)
四川省国际科技创新合作项目(2020YFH0156)
成都市科技局项目(2022YF0501021SN)。
